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Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?

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Carolina Porras et al.

Summary: Vaccination of adolescent girls with HPV vaccines is essential for preventing cervical cancer. Studies suggest that a single dose of the vaccine may provide long-lasting protection and reduce the risk of cervical cancer. Large trials are currently underway to compare the efficacy of one versus two doses of different HPV vaccines in preventing new HPV infections.

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Louise Baandrup et al.

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Sustainability of neutralising antibodies induced by bivalent or quadrivalent HPV vaccines and correlation with efficacy: a combined follow-up analysis of data from two randomised, double-blind, multicentre, phase 3 trials

Filipe Colaro Mariz et al.

Summary: This study tracked the data from two international HPV vaccine trials in Finland, and found that HPV vaccine-induced antibodies can last up to 12 years after vaccination. Significant differences were observed in the neutralising antibody efficacy and cross-neutralising antibody efficacy between quadrivalent and bivalent vaccine recipients, which correlated with vaccine efficacy.

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Summary: This study in India compared the efficacy of single dose HPV vaccine with two and three doses in protecting against persistent HPV 16 and 18 infection over a 10-year period. The research found that a single dose of the vaccine provided similar protection against these infections as two or three doses, which are responsible for nearly 70% of cervical cancers.

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A dose-reduction HPV vaccine immunobridging trial of two HPV vaccines among adolescent girls in Tanzania (the DoRIS trial) - Study protocol for a randomised controlled trial

Kathy J. Baisley et al.

Summary: This study in Tanzania aims to determine whether a single dose of HPV vaccine can produce effective immune responses to prevent cervical cancer. Results will be compared to historical cohorts with established efficacy to evaluate the quality and durability of immune responses in reduced dose schedules.

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Ebola vaccine-induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects

Michelle Meyer et al.

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Inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response

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