REVISOR, COMMENTED ON BY ALL GOGOL. ALEXANDER SLONIMSKY AND YULIA SAZONOVA-SLONIMSKAYA IN THE CONTROVERSY ABOUT THE MEYERHOLD PLAY

An increasing corpus of research has demonstrated that membrane shape, gen-erated either by the external environment of the cell or by intrinsic mechanisms such as cytokinesis and vesicle or organelle formation, is an important parameter in the control of diverse cellular processes. In this review we discuss recent find-ings that demonstrate how membrane curvature (from nanometer to micron length-scales) alters protein function. We describe an expanding toolkit for experi-mentally modulating membrane curvature to reveal effects on protein function, and discuss how membrane curvature - far from being a passive consequence of the physical environment and the internal protein activity of a cell - is an important sig-nal that controls protein affinity and enzymatic activity to ensure robust forward pro-gression of key processes within the cell.

Automated summary

An increasing corpus of research has shown that membrane shape, generated by the external environment or intrinsic mechanisms, is an important parameter in controlling cellular processes. Recent findings demonstrate how membrane curvature affects protein function on nanometer to micron length-scales. Experimental modulation of membrane curvature reveals its role as a signal that controls protein affinity and enzymatic activity, ensuring the progression of key cellular processes.