Functional molecules and nano-materials for the Golgi apparatus-targeted imaging and therapy

The Golgi apparatus is a dynamic membrane-bounded flattened cisternae in eukaryotic cells and responsible for biosynthesis, secretion, and intracellular signaling transduction. The dysfunction of the Golgi apparatus is related to a series of diseases including cancers and neurodegenerative diseases. Sensitive and selective imaging of the Golgi structure or Golgi-related biomolecules provide valuable tools for in-depth understanding of the Golgi structure-function relationship and Golgi-related diseases. The last two decades have witnessed an explosion in the Golgi-targeting strategies, the combination of which with new imaging methods and nanotechnologies providing valuable tools for the Golgi-targeted biosensing, drug discovery and therapy. This review summarizes the different strategies for the Golgi imaging and therapy from historical origin to current development, discusses the advantages and limitations, and highlights possible future directions.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

The Golgi apparatus in eukaryotic cells plays a crucial role in biosynthesis, secretion, and intracellular signaling. Dysfunctions in the Golgi apparatus are associated with various diseases. Sensitivity and selectivity in imaging the Golgi structure and related biomolecules have provided valuable tools for understanding the relationship between Golgi structure and function, as well as Golgi-related diseases. Recent advancements in Golgi-targeting strategies, imaging methods, and nanotechnologies have opened up possibilities for Golgi-targeted biosensing, drug discovery, and therapy. This review summarizes the different strategies for Golgi imaging and therapy, discusses their advantages and limitations, and highlights potential future directions.