期刊
TOXICOLOGY IN VITRO
卷 83, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2022.105421
关键词
Nanosilica; Biocompatible; Platelets; Coagulation; Thrombus; Mesoporous silica
类别
资金
- Department of Science and Technology (DST), Government of India [DST/NM/NB/2018/40 (G)]
- INSPIRE Faculty Research grant [IFA-LSBM-31]
This study evaluated the interaction between nanosilica and the blood coagulation system, and found that nanosilica has no stimulatory effect on platelets and no effective interaction with coagulation proteins.
Nanosilica is widely employed in various biomedical applications because of their tailorable physiochemical properties and excellent biocompatibility. In the present study, we have evaluated interaction of nanosilica with important coagulation components, such as platelets, a highly sensitive cell found in the blood, and coagulation proteins. Mesoporous silica nanoparticles (MSNs) were prepared using sol-gel process and characterized by FESEM and TEM to find out the size and shape of the particles. Different platelet functional parameters including platelet adhesion, aggregation, activation, secretion, clot formation and clot retraction-based studies have been carried out to investigate the impact of synthesized nanosilica on the blood coagulation system. Besides, ROS generation and increase in intracellular calcium was also monitored as they play a pivotal role in regulating platelet functions. The complete detailed study revealed that MSNs neither has stimulatory action towards platelets nor do they show any effective interaction with coagulation proteins.
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