Analysis of the extracorporeal anticoagulation effect of modified citrate infusion during continuous renal replacement therapy in critically ill patients

Introduction To analyze the anticoagulation effect of different local infusion methods of citrate underwent continuous renal replacement therapy (CRRT) in critically ill patients. Methods The study adopted a single-centre retrospective design. Critically ill patients were divided into conventional group and modified group based on the infusion methods of citrate. Results The modified group had a longer mean treatment time (67.67 +/- 18.69 hours vs. 52.11 +/- 24.26 hours, p = 0.007), a lower transmembrane pressure (147.77 +/- 66.85 cm H2O vs. 200.63 +/- 118.66 cm H2O, p = 0.038), fewer citrate bag replacements (1.43 +/- 0.50 times vs. 10.60 +/- 3.19 times, p < 0.001), and more steady ionized calcium at the venous end (0.35 +/- 0.06 mmol/L vs. 0.40 +/- 0.05 mmol/L, p = 0.006) compared to the conventional group patients, with statistically significant differences. The incidences of citrate accumulation and tubing coagulation were marginally lower in the modified group. Conclusion The modified local citrate infusion method can prolong treatment time, while reducing both the nursing workload and the occurrence of citrate accumulation.

Automated summary

This study analyzed the anticoagulation effect of different local infusion methods of citrate in critically ill patients undergoing CRRT. The modified group had longer treatment time, lower transmembrane pressure, fewer citrate bag replacements, and more stable ionized calcium levels compared to the conventional group. The incidences of citrate accumulation and tubing coagulation were marginally lower in the modified group.