Pyridine-promoted diazotization of P-H bonds with aryl diazonium tetrafluoroborates: Synthesis of azo organophosphorus compounds

A pyridine-promoted diazotization of P-H bonds with aryl diazonium tetrafluoroborates is established. The reported method is simple and efficient for the synthesis of azo organophosphorus compounds with excellent yields, which avoids the adoption of complex and harsh reaction conditions and the addition of oxides, tolerating various kinds of functional groups. The synthesized azo organophosphorus compounds may have potential applications in organic chemistry and drug design.(c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

A pyridine-promoted diazotization of P-H bonds with aryl diazonium tetrafluoroborates is reported. The method is simple and efficient, providing azo organophosphorus compounds with excellent yields. It avoids the need for complex and harsh reaction conditions and the addition of oxides, and is tolerant to various functional groups. The synthesized azo organophosphorus compounds may find potential applications in organic chemistry and drug design.