4.4 Article

Design, synthesis, antigiardial and in silico assessments of novel propargylamines containing nitroimidazole core

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Summary: Propargylamines are important alkyne-coupled amine compounds used in heterocyclic chemistry and pharmaceuticals, often synthesized through A3 coupling. While metal-catalyzed methods are commonly used, there is a growing interest in metal-free techniques for their synthesis. This review article discusses the comprehensive study of metal-free protocols in propargylamine synthesis.

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