期刊
TETRAHEDRON
卷 125, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2022.133060
关键词
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资金
- Chongqing Science Funds for Distinguished Young Scientists [cstc2020jcyj-jqX00 05]
- 2035 pilot plan for innovative research of Southwest University, China [SWU-XDPY220 09]
A new fungal nonribosomal peptide-polyketide hybrid synthase, named CogA, was discovered through genome mining from fungus Cordyceps gunnii. Its ability to synthesize 4-hydroxyl 2-pyrrolidinone alkaloid (1) through nonenzyme-catalyzed N-1-C-2 closure was confirmed by heterologous expression in Aspergillus nidulans. Furthermore, the engineered biosynthesis of fluoro-substituted 2-pyrrolidinone alkaloid analogues (4 and 5) has also been achieved in vivo.
A new fungal nonribosomal peptide-polyketide hybrid synthase, namely CogA, was discovered by genome mining from fungus Cordyceps gunnii. Its ability to synthesize 4-hydroxyl 2-pyrrolidinone alkaloid (1) via nonenzyme-catalyzed N-1-C-2 closure was confirmed by heterologous expression of it in Aspergillus nidulans. Further engineered biosynthesis of the fluoro-substituted 2-pyrrolidinone alka-loid analogues (4 and 5) has also been achieved in vivo.(c) 2022 Elsevier Ltd. All rights reserved.
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