期刊
TALANTA
卷 249, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2022.123689
关键词
Teriflunomide; Molecularly imprinted polymer; Electropolymerization; Voltammetry; Drug analysis
资金
- Council of Higher Education [100/2000]
- TUBITAK [BIDEB/2211-A]
- Scientific and Technological Research Council of Turkey (TUBITAK) [BIDEB/2218]
In this study, pyrrole-histidine has been used as a novel functional monomer to fabricate a molecularly imprinted electrochemical sensor for the selective and sensitive detection of teriflunomide (TER). The developed sensor showed a linear response to TER with low detection limit, and demonstrated excellent recovery rates in synthetic serum samples and tablet dosage form.
In this work, pyrrole-histidine has been designed, synthesized and, used as a novel functional monomer to fabricate a molecularly imprinted electrochemical sensor for the selective and sensitive detection of teriflunomide (TER). The molecularly imprinted thin film of electrochemical sensor was constructed by directly electropolymerization of co-polymer of pyrrole-histidine (PyHis) with pyrrole in the presence of a template, TER, on a glassy carbon electrode (GCE). After electropolymerization, the structure and morphology of the fabricated MIP sensor were characterized by Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) and its electrochemical parameters such as cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS). The poly (pyrrole-co-pyrrole-histidine) [Poly (Py-co-PyHis)]@MIP/GCE sensor have a linear TER concentration in the of 0.1-1.0 pM with a low detection limit of 11.38 fM. The present strategy for electrochemical sensor have been also showed excellent recovery in synthetic serum samples and tablet dosage form with the recoveries 97.56% and 100.35%, respectively. The developed [Poly (Py-co-PyHis)]@MIP/GCE sensor exhibited an excellent electrochemical response for TER due to the synergistic effect of conducting polymer and molecularly imprinting techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据