4.1 Article

Clinical Trials in Melanoma Margins, Lymph Nodes, Targeted and Immunotherapy

期刊

出版社

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.soc.2022.07.005

关键词

Melanoma; Surgical margins; Sentinel lymph node; Targeted therapy; Immunotherapy

向作者/读者索取更多资源

The current guidelines for the surgical care of cutaneous melanoma have been shaped by multiple randomized controlled clinical trials. These trials have provided important guidance for margin excision and sentinel lymph node biopsy in melanoma patients, and the development of targeted therapy and immunotherapy has offered effective adjuvant treatment options.
The current guidelines for the surgical care of cutaneous melanoma have been shaped by multiple randomized controlled clinical trials. Six prospective randomized trials performed between 1980 and 2004 have informed the current NCCN guidelines for margin excision in melanoma, and the currently enrolling MelMarT trial will provide important information on the safety of narrower surgical margins for thicker lesions in the era of SLNB. MSLT-I led to the common practice of SLNB for patients with intermediate thickness and thick melanomas primarily for prognostication and staging, and MSLT-II and DECOG-SLT demonstrated safety in observing the nodal basin with serial ultrasound compared with immediate CLND in patients with a positive sentinel node. Additionally, for patients with nodal disease (stage III), recent developments in targeted and immune therapy have led to effective adjuvant therapy options with demonstrated improvements in RFS. As the melanoma landscape continues to evolve with an increasing interest in neoadjuvant therapy approaches, it is anticipated that future clinical trials will continue to change practice, improving the care for patients with cutaneous melanoma.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据