The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis

Article Biochemistry & Molecular Biology

The carbohydrate-active enzyme database: functions and literature

Elodie Drula et al.

Summary: The CAZy database, freely available for browsing and download, is deeply rooted in human curation and plays a crucial role in maintaining and updating family classification, classifying new sequences, and presenting functional information. Over the past 8 years, there has been an increase in novel families and extensive annotations conducted, highlighting the significant amount of work involved in analyzing and reporting biochemical data from the literature.

NUCLEIC ACIDS RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Zachary Armstrong et al.

Summary: This study used cryo-EM to determine the three-dimensional structure of human lysosomal α-L-fucosidase, revealing its structural characteristics, the architecture of the catalytic center, and the location of natural population variations and disease-causing mutations. Furthermore, the study identified the catalytic acid/base and its shift from the canonical glutamate residue. These findings provide important insights into the function of FucA1 in both health and disease.

STRUCTURE (2022)

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Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

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Review Genetics & Heredity