The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis

In this issue of Structure, Armstrong and colleagues probe the structure of human fucosidase FucA1. Their work resolves an ongoing debate around the enzyme's catalytic mechanism and provides a valid structural template to guide the design of drugs alleviating the rare, yet severe, lysosomal storage disease fucosidosis.

Automated summary

In this study, Armstrong and his team investigate the structure of human fucosidase FucA1. Their findings not only resolve the debate on the enzyme's catalytic mechanism but also offer a valuable structural template for the design of drugs to treat fucosidosis, a rare but severe lysosomal storage disease.