☆ 4.7 Biographical-Item

In Memoriam: Jim Toole, MD: Ahead of His Time

STROKE (2022)

James Francis Toole (1925-2021) Obituary

E. Steve Roach

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2022)

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Article Multidisciplinary Sciences

DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial

Nicole M. Davis Armstrong et al.

Summary: Aberrant DNA methylation profiles have been linked to various cardiovascular diseases, with few studies focusing on stroke recurrence. This study identified methylation loci associated with recurrent cerebro- and cardiovascular events, revealing significant loci and modules related to clinical traits and blood biomarkers. Results suggest potential epigenetic biomarkers for identifying at-risk individuals in recurrence-prone populations.

PLOS ONE (2021)

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Article Clinical Neurology