期刊
STATISTICAL METHODS IN MEDICAL RESEARCH
卷 31, 期 12, 页码 2442-2455出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/09622802221122418
关键词
Bayesian approach; Chen distribution; cure rate model; survival regression analysis
The present study introduces a new multivariate mixture cure rate model for modeling recurrent event data in the presence of cure fraction. The study provides an alternative approach for analyzing bivariate lifetime data with covariates, censored data, and cure fraction using a new bivariate parametric model.
The present study introduces a new multivariate mixture cure rate model based on the Chen probability distribution to model recurrent event data in the presence of cure fraction. In this context, we provide an alternative for the use of some usual modeling approaches as the semiparametric Cox proportional hazards model commonly used in lifetime data analysis, considering a new bivariate parametric model to be used in the data analysis of bivariate lifetime data assuming a mixture structure for the bivariate data in presence of covariates, censored data and cure fraction. Under a Bayesian setting, the proposed methodology was considered to analyze two real medical datasets from a retrospective cohort study related to leukemia and diabetic retinopathy diseases. The model validation process was addressed by using the Cox-Snell residuals, which allowed us to identify the suitability of the new proposed mixture cure rate model.
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