期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 280, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2022.121499
关键词
Fluorescent probe; Detection; N2H4; ESIPT; Imaging
类别
资金
- National Natural Science Foundation of China (NSFC) [32072464]
- Scientific Research Start-up Fund for Introduced Talents of Anhui Polytechnic University [2021YQQ052]
- National Natural Science Foundation of China Pre-Research Project for Anhui Polytechnic University [Xjky2022107]
A novel fluorescent probe, BRBA, has been developed for selective detection of hydrazine under complex conditions. The probe exhibits low cytotoxicity and a large Stokes shift, making it suitable for monitoring environmental water samples and imaging cells.
Hydrazine (N2H4), an important chemical intermediate, has been widely used in industrial production and agricultural life, but it has also caused environmental pollution. A novel ESIPT-based fluorescent probe with dual recognition sites, 2-(benzothiazole-2-yl)-1,4-imphenyl bis 4-bromobutyric acid (BRBA), was developed to selectively detect N2H4 under complex conditions. BRBA exhibits accurate detection for N2H4 with a good linear relationship ranging from 0 to 150 mu M, and the LOD can reach 0.1 mu M. Importantly, taking advantage of low cytotoxicity and a large Stokes shift, BRBA can be utilized to monitor environmental water samples and successfully applied to imaging HeLa cells and zebrafish.
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