Water dispersible superparamagnetic Cobalt iron oxide nanoparticles for magnetic fluid hyperthermia

Superparamagnetic nanoparticles of Cobalt iron oxide (CoFe2O4) are synthesized chemically, and dispersed in an aqueous suspension for hyperthermia therapy application. Different parameters such as magnetic field intensity, particle concentration which regulates the competence of CoFe2O4 nanoparticle as a heating agents in hyperthermia are investigated. Specific absorption rate (SAR) decreases with increase in the particle concentration and increases with increase in applied magnetic field intensity. Highest value of SAR is found to be 91.84 W g(-1) for 5 mg. mL(-1) concentration. Oleic acid conjugated polyethylene glycol (OA-PEG) coated CoFe2O4 nanoparticles have shown superior cyto-compatibility over uncoated nanoparticles to L929 mice fibroblast cell lines for concentrations below 2 mg. mL(-1). Present work provides the underpinning for the use of CoFe2O4 nanoparticles as a potential heating mediator for magnetic fluid hyperthermia. (C) 2016 Elsevier B.V. All rights reserved.