期刊
SMALL
卷 18, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202204588
关键词
antibiotics detection; cavity-in-cavity; machine learning; plasmonic; surface-enhanced Raman scattering
类别
资金
- National Key Research and Development Program Projects [2021YFA1201500]
- National Natural Science Foundation of China [11974069, 61805033, 31871873, 61903235]
- Liao Ning Revitalization Talents Program [XLYC1902113]
- Science and Technology Project of Liaoning Province [2020JH2/10100012]
- Dalian High-level Talent Innovation Support Program [2019RQ028]
This study proposes a machine learning-driven 3D plasmonic cavity-in-cavity SERS platform for sensitive and quantitative detection of antibiotics. The application of this platform enables quantitative analysis of antibiotics at different concentrations.
The surface-enhanced Raman scattering (SERS) technique with ultrahigh sensitivity has gained attention to meet the increasing demands for food safety analysis. The integration of machine learning and SERS facilitates the practical applicability of sensing devices. In this study, a machine learning-driven 3D plasmonic cavity-in-cavity (CIC) SERS platform is proposed for sensitive and quantitative detection of antibiotics. The platform is prepared by transferring truncated concave nanocubes (NCs) to an obconical-shaped template surface. Owing to the triple synergistic enhancement effect, the highly ordered 3D CIC arrays improve the simulated electromagnetic field intensity and experimental SERS activity, demonstrating a 33.1-fold enhancement compared to a typical system consisting of Au NCs deposited on a flat substrate. The integration of machine learning and Raman spectroscopy eliminates subjective judgments on the concentration of detectors using a single feature peak and achieves accurate identification. The machine learning-driven CIC SERS platform is capable of detecting ampicillin traces in milk with a detection limit of 0.1 ppm, facilitating quantitative analysis of different concentrations of ampicillin. Therefore, the proposed platform has potential applications in food safety monitoring, health care, and environmental sampling.
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