期刊
SMALL
卷 18, 期 49, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202203659
关键词
ferrocene; ferroptosis; iridium(III) complex; photoimmunotherapy; self-amplifying
类别
资金
- National Natural Science Foundation of China [22022707, 22177142, 21837006, 91953117]
- Fundamental Research Funds for the Central Universities
This study presents a new ferrocene-containing Ir(III) photosensitizer that can be transported into TNBC cells and induce ferroptosis through a self-amplifying process. Treatment with this photosensitizer enhances anticancer immunity by activating immunogenic cell death in TNBC cells.
Photoimmunotherapy is attractive for cancer treatment due to its spatial controllability and sustained responses. This work presents a ferrocene-containing Ir(III) photosensitizer (IrFc1) that can bind with transferrin and be transported into triple-negative breast cancer (TNBC) cells via a transferrin receptor-mediated pathway. When the ferrocene in IrFc1 is oxidized by reactive oxygen species, its capability to photosensitize both type I (electron transfer) and type II (energy transfer) pathways is activated through a self-amplifying process. Upon irradiation, IrFc1 induces the generation of lipid oxidation to cause ferroptosis in TNBC cells, which promotes immunogenic cell death (ICD) under both normoxia and hypoxia. In vivo, IrFc1 treatment elicits a CD8(+) T-cell response, which activates ICD in TNBC resulting in enhanced anticancer immunity. In summary, this work reports a small molecule-based photosensitizer with enhanced cancer immunotherapeutic properties by eliciting ferroptosis through a self-amplifying process.
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