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Polymeric Dendrimers as Nanocarrier Vectors for Neurotheranostics

SMALL (2022)

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Article Nanoscience & Nanotechnology

Anchoring Group-Mediated Radiolabeling of Inorganic Nanoparticles-A Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes

Jianxian Ge et al.

Summary: This study demonstrates the universality of a simple and efficient radiolabeling method, LAGMERAL, for constructing radioactive nanoprobes. The method utilizes a diphosphonate-polyethylene glycol (DP-PEG) group on the surface of inorganic nanoparticles for efficient radiolabeling. The resulting nanoprobes exhibit high radiolabeling stability and biocompatibility, making them promising for sensitive tumor diagnosis. This research highlights the importance and potential of LAGMERAL in nuclear medicine imaging.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Self-Illuminating Triggered Release of Therapeutics from Photocleavable Nanoprodrug for the Targeted Treatment of Breast Cancer

Fengjun Sun et al.

Summary: This study synthesized a photocleavable nanoprodrug that can release an antitumor drug through UV light. The nanoprodrug was efficiently internalized by tumor cells, leading to a significant inhibition of tumor growth.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Pharmacology & Pharmacy

Mechanisms of immune response to inorganic nanoparticles and their degradation products

Raziye Mohammapdour et al.

Summary: Research has elucidated the cellular and molecular mechanisms of interaction between inorganic nanoparticles and the immune system, with a specific focus on the immune response to the degradation products. The importance of designing new methods and instruments for assessing the safety of inorganic nanoparticles was emphasized.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Engineering, Biomedical

Preparation and characterization of polyamidoamine dendrimers conjugated with cholesteryl-dipeptide as gene carriers in HeLa cells

Le Thi Thuy et al.

Summary: Improving the transfection efficiency of non-viral carriers using cationic polymers like PAMAM G2-HRChol is a promising approach in gene therapy. These polymers have functional groups that enhance DNA condensation and cellular uptake, leading to improved endosomal escape and lower cytotoxicity compared to other carriers like PEI 25 kDa. Cholesterol incorporation in PAMAM G2-HRChol further enhances the gene transfection efficiency, making it a potential gene carrier in HeLa cells.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2022)

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Review Biotechnology & Applied Microbiology

Histidine-enhanced gene delivery systems: The state of the art

Seyyed Emad Hooshmand et al.

Summary: Gene therapy using histidine-based carriers has shown promise in delivering nucleic acids into target cells. This review discusses the diversity and biocompatibility of histidine-enhanced gene delivery systems, as well as the conjugation methods with linear polymers. The challenges, opportunities, and future research trends of histidine-based gene delivery are also investigated.

JOURNAL OF GENE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery

Li Li et al.

Summary: An intelligent stimulus-triggered release dual-responsive hydrogel was designed and synthesized in this study. It can respond to the heterogeneity of GSH and pH conditions in tumors, with a high drug loading capacity and controlled release behavior. The Dox-loaded hydrogel exhibited comparable anti-tumor activity to the positive control.

MOLECULES (2022)

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Review Polymer Science

Polymer-based non-viral vectors for gene therapy in the skin

Luz Tortajada et al.

Summary: This review discusses the chemical approaches and challenges, ongoing clinical trials, and prospects of polymer-based non-viral gene delivery systems for the treatment of skin diseases.

POLYMER CHEMISTRY (2022)

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Review Engineering, Biomedical

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Shuai Zha et al.

Summary: Intranasal delivery of nanoparticles offers a non-invasive and effective method for delivering therapeutic agents to the brain, bypassing the blood-brain barrier.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Pharmacology & Pharmacy

Dendrimers in the context of targeting central nervous system disorders

Forum Palan et al.

Summary: Dendrimers have garnered significant interest as a noninvasive strategy for delivering drugs across the blood-brain barrier to treat central nervous system disorders. While research has shown their effectiveness in various CNS disorders, their entry into clinical trials remains restricted.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Formulation development of tocopherol polyethylene glycol nanoengineered polyamidoamine dendrimer for neuroprotection and treatment of Alzheimer disease

Ajit Singh et al.

Summary: The study found that PIP-TPGS-PAMAM can mitigate the neurotoxicity induced by A beta(1-42) and has great potential in neuroprotection and AD therapy.

JOURNAL OF DRUG TARGETING (2022)

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Article Biochemistry & Molecular Biology

Nanoscaled PAMAM Dendrimer Spacer Improved the Photothermal-Photodynamic Treatment Efficiency of Photosensitizer-Decorated Confeito-Like Gold Nanoparticles for Cancer Therapy

Wen Shang Saw et al.

Summary: In this study, the researchers improved the efficiency of photothermal-photodynamic cancer treatment by using PAMAM dendrimers as spacers between the photosensitizer-gold nanoparticles (PS-AuNP) system. They found that the PS-PAMAM-confeito-AuNPs demonstrated better cancer cell-killing efficacy, higher phototoxicity, and selective tumor accumulation effect compared to directly conjugated photosensitizers.

MACROMOLECULAR BIOSCIENCE (2022)

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Article Chemistry, Analytical

Detection of Aβ oligomers in early Alzheimer's disease diagnose by in vivo NIR-II fluorescence imaging

Hengde Li et al.

Summary: This study reports a novel functional probe that responds to A beta oligomers, the biomarkers of early-stage Alzheimer's disease (AD), through near-infrared window (NIR-II) fluorescence imaging. The probe has high selectivity, preferentially targeting A beta oligomers and readily crossing the blood-brain barrier.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Biochemistry & Molecular Biology

Metal-Free Radical Dendrimers as MRI Contrast Agents for Glioblastoma Diagnosis: Ex Vivo and In Vivo Approaches

Songbai Zhang et al.

Summary: MRI is a highly required imaging approach for the early diagnosis and follow-up of tumors, especially brain cancer. Organic radicals anchored on a dendrimer macromolecule surface show promising potential as alternatives to traditional Gd-based contrast agents, with similar contrast enhancement effects, lower toxicity, and longer biological stability.

BIOMACROMOLECULES (2022)

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Article Biophysics

Theoretical evaluation of poly(amidoamine) dendrimers with different peripheral groups as a purinethol drug delivery system in aqueous medium

Ramadan Al-Shdefat et al.

Summary: Density functional theory calculations were used to study the association of PUR with amine-and acetyl-terminated PAMAM dendrimers. The electronic properties of dendrimers are sensitive to the presence of PUR molecule. Encapsulation of PUR molecule leads to a significant change in Gibbs free energy, and the drug molecule is easily released at low pH. Acetylation can improve the release pattern of drug molecule.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Review Oncology

Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

Eunus S. Ali et al.

Summary: Nanotechnology is reshaping healthcare strategies with a tremendous impact, especially in the fields of medical diagnostics and drug delivery, offering potential for improved effectiveness and sustainability in treating diseases like cancer. The application of nano-level elements can reduce drug toxicities and enhance drug delivery efficiency.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Entomology

Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management

Shuo Yan et al.

Summary: Nanoparticle-mediated RNAi offers advantages in delivering dsRNA/small interfering RNA to improve efficiency, promoting the development and practice of RNAi-based pest management strategies.

INSECT SCIENCE (2021)

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Review Chemistry, Medicinal

Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs

Serge Mignani et al.

Summary: The article discusses various ways to deliver drugs to the brain through intranasal administration, bypassing the blood-brain barrier, with an emphasis on the potential of dendrimers as nanocarriers to reduce systemic exposure and side effects.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

Maltoheptaose-Presenting Nanoscale Glycoliposomes for the Delivery of Rifampicin to E. coli

Bin Wu et al.

Summary: Liposomes, especially G7-glycoliposomes, loaded with rifampicin showed improved antibacterial activity, with fluid G7-glycoliposomes exhibiting the best sustained activity against E. coli. Introduction of carbohydrates in the liposomes slowed down the release of rifampicin, leading to a lower permeability coefficient. The multivalent G7-glycoliposomes had significantly stronger affinity towards Con A compared to the binding between Con A and G7.

ACS APPLIED NANO MATERIALS (2021)

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Review Engineering, Biomedical

PEGYLATION: an important approach for novel drug delivery system

Deepa Yadav et al.

Summary: PEGylation is a technique for improving the maintenance time and beneficial properties of drugs by covalently attaching polyethylene glycol (PEG) to molecules. It plays an important role in enhancing the therapeutic potential and drug delivery system，and is widely used in pharmaceutical field to improve drug properties.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

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Article Engineering, Biomedical

Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by HA for targeted gene delivery systems and evaluationin vitro

Haimei Hu et al.

Summary: Poly(amido-amine) (PAMAM) modified by hyaluronic acid (HA) showed reduced cytotoxicity and smaller particle size, with improved DNA delivering capacity in cancer cells line. The transfection efficiency of the modified polymers approached that of unmodified polyplexes, making them potential candidates for targeted gene delivery.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

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Article Nanoscience & Nanotechnology

Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury

Myoungjee Choi et al.

Summary: The dendrimer micelles with glycyrrhizic acid (GA) successfully integrated the anti-inflammatory drug GA and improved gene delivery efficiency. By enhancing cellular uptake, increasing gene delivery efficiency to the lungs, and interacting with the GA receptor, the micelles showed enhanced transfection efficiency.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Nanoassemblies with Effective Serum Tolerance Capability Achieving Robust Gene Silencing Efficacy for Breast Cancer Gene Therapy

Hongmei Liu et al.

Summary: A novel PEG modification strategy was proposed in this study, forming PEG/G5PBA/siRNA nanoassemblies through reversible boronate esters, which significantly improved siRNA delivery efficiency under both serum-free and serum-containing conditions.

ADVANCED MATERIALS (2021)

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Review Engineering, Biomedical

Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges

Xin Gao et al.

Summary: This review focuses on the principles and methods in the design of targeted nanoparticles for the diagnosis and therapy of orthotopic and metastatic bone tumors. Various ligands have been grafted on nanoparticles for bone targeting, and different targeting strategies using monoclonal antibodies, peptides, and aptamers have been explored for diagnosis and therapy. The development of multifunctional nanoparticles to disrupt the vicious cycle between tumor cell proliferation and bone resorption, as well as the challenges and perspectives in this area, are also discussed.

BIOMATERIALS (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Chemistry, Applied

Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy

Min Li et al.

Summary: Polysaccharide-based biomaterials hyaluronic acid (HA) and chondroitin sulfate (CS) have attracted attention for drug delivery in tumor therapy due to their excellent biocompatibility and targeting ability for cluster determinant 44 (CD44). This review covers the formation and various types of CS-based NPs, as well as the applications of HA- and CS-based NPs in tumor chemotherapy, gene therapy, and other cancer therapies.

CARBOHYDRATE POLYMERS (2021)

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Article Pharmacology & Pharmacy

Dual functional nanoparticles efficiently across the blood-brain barrier to combat glioblastoma via simultaneously inhibit the PI3K pathway and NKG2A axis

Zheng Jin et al.

Summary: This study developed a novel dual functional dendrimer drug delivery system for efficient inhibition of glioblastoma by crossing the blood-brain barrier and overcoming the immunosuppressive microenvironment within the tumor tissues. The system was able to simultaneously inhibit tumor-promoting signaling pathways and activate anti-tumor immunity, providing a promising strategy for combating glioblastoma.

JOURNAL OF DRUG TARGETING (2021)

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Article Polymer Science

An insight into aptamer engineered dendrimer for cancer therapy

Afsana Sheikh et al.

Summary: Aptamers are crucial in drug delivery but prone to degradation by endonucleases; bioconjugation with dendrimers offers a novel platform for improved targeted drug delivery system.

EUROPEAN POLYMER JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Uncovering the Metabolic Origin of Aspartate for Tumor Growth Using an Integrated Molecular Deactivator

Ruixue Duan et al.

Summary: The study designed a molecular deactivator based on upconversion nanoprobes to investigate the link between glucose and aspartate, revealing that cellular synthesis of aspartate for tumor growth is dependent on glucose. The research demonstrates the potential of molecularly engineered upconversion nanoprobes in discovering hidden metabolic pathways and enhancing the effectiveness of conventional antitumor drugs.

NANO LETTERS (2021)

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Article Pharmacology & Pharmacy

Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression

Asmaa M. Elfiky et al.

Summary: This study demonstrated the potential of LA-PAMAM carrier for targeted delivery of tumor suppressor miR-218 as a therapeutic candidate for HCC. The combination of hyperbranched polyamidoamine and lactobionic acid efficiently suppressed HepG2 cell proliferation and down-regulated the oncogenic HOXA1 target.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Dual-Targeting Peptide-Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform

Shuai Zha et al.

Summary: A novel dual-EBV-oncoproteins-targeting peptide engineering approach was introduced to achieve precision targeting and treatment strategy against EBV-associated cancers. By specifically binding to overexpressed EBV-specific oncoproteins, this method showed higher cellular uptake and accumulation in EBV-infected cells, leading to effective cancer inhibition in vitro and in vivo.

ADVANCED SCIENCE (2021)

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Review Chemistry, Multidisciplinary

RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy

Afsana Sheikh et al.

Summary: A bird's eye view is needed in cancer research to address the shortcomings of chemotherapy, with targeted therapy showing promise in providing more efficient treatment for tumor cells.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Environmental

Biodegradable antibacterial branched glycerol-polypeptide with efficient in vitro/in vitro miRNA-29b delivery for promoting osteogenic differentiation of stem cells and bone regeneration

Yi Guo et al.

Summary: A novel antibacterial non-viral vector based on branched glycerol-polypeptide polymer (GEPL) was developed for efficient miR-29b delivery to regulate osteogenic differentiation of bone marrow stem cells (BMSCs) and in vivo bone regeneration. Compared to other vectors, GEPL showed excellent biocompatibility and significantly improved bone tissue regeneration in vivo.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Enhancing Hybrid Upconversion Nanosystems via Synergistic Effects of Moiety Engineered NIR Dyes

Guochen Bao et al.

Summary: The introduction of the bulky moiety TPEO significantly improves the quantum yield and photostability of the NIR dye, resulting in the formation of TPEO-Cy with significantly enhanced properties. Binding TPEO-Cy to the surface of UCNPs leads to a synergistic effect, achieving a significantly enhanced upconversion emission compared to conventional systems.

NANO LETTERS (2021)

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Review Pharmacology & Pharmacy

Strategies for cancer gene-delivery improvement by non-viral vectors

Maria L. Santana-Armas et al.

Summary: Gene therapy is an emerging strategy for cancer treatment, and modifying non-viral vectors can enhance safety and efficiency. Structural modifications, addition of specific ligands, and other methods can improve the specificity and gene delivery efficiency of non-viral vectors.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Brain gene delivery using histidine and arginine-modified dendrimers for ischemic stroke therapy

Youngki Lee et al.

Summary: Polyamidoamine dendrimer, specifically PG2HR with histidine and arginine conjugation, has shown higher gene delivery efficiency and lower cytotoxicity compared to commonly used PG6. It has demonstrated potential for gene therapy of inflammatory diseases, including ischemic stroke, due to its improved cellular uptake and endosomal escape.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biotechnology & Applied Microbiology

Strategies for delivering therapeutics across the blood-brain barrier

Georg C. Terstappen et al.

Summary: The blood-brain barrier presents a challenge for delivering therapeutics to the central nervous system, particularly for biopharmaceuticals. Non-invasive approaches have been developed to help overcome this challenge, with increasing research efforts focusing on technologies to deliver therapeutics to the CNS, some of which have entered clinical testing. Developing effective strategies for crossing the blood-brain barrier is crucial for treating CNS disorders, with a particular emphasis on non-invasive methods such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles, and exosomes.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Biotechnology & Applied Microbiology

Nanotechnology against human cytomegalovirus in vitro: polyanionic carbosilane dendrimers as antiviral agents

I. Relano-Rodriguez et al.

Summary: Polyanionic carbosilane dendrimers have shown potential application in inhibiting HCMV infection and enhancing the activity of current treatments, representing a low-cost approach to fight HCMV infections.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines

Zehua Liu et al.

Summary: The article summarizes the requirements and obstacles for fabricating non-viral nano-vectors for efficient RNAi, and discusses practical guidelines to address the delivery challenges. Additionally, the current status of clinical translation of RNAi-based therapies and further perspectives for reducing potential side effects are reviewed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Polymer Science

Application of Non-Viral Vectors in Drug Delivery and Gene Therapy

Shuaikai Ren et al.

Summary: This review highlighted the importance of non-viral vectors in gene therapy and drug delivery, due to their low immunogenicity, good biocompatibility, easy synthesis and modification, and low cost of production. The review summarized various non-viral vectors including polymers, liposomes, gold nanoparticles, mesoporous silica nanoparticles and carbon nanotubes, discussing their physicochemical characteristics, synthesis methods, functional modifications, and research applications, as well as future research directions.

POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Core-Shell Tecto Dendrimers Enable Enhanced Tumor MR Imaging through an Amplified EPR Effect

Cong Song et al.

Summary: Development of core-shell tecto dendrimers (CSTDs) as a platform for enhanced tumor magnetic resonance (MR) imaging through an amplified enhanced permeability and retention (EPR) effect. The generated CSTD-D-Gd complexes have a longer rotation correlation time, hence possess a higher longitudinal relaxivity compared to single dendrimer counterpart.

BIOMACROMOLECULES (2021)

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Review Neurosciences

Imaging of Neurotrauma in Acute and Chronic Settings

Shane Mallon et al.

Summary: In traumatic injuries of the brain and spinal cord, severe and prolonged inflammation plays a key role, leading to damaging effects on blood vessels and persistent vasogenic edema. Imaging evaluation is crucial for identifying abnormalities requiring immediate intervention and has potential applications for neuroprotective therapies. Neuroimaging is essential for diagnosis and guiding therapy in neurotrauma research and clinical trials.

CURRENT NEUROPHARMACOLOGY (2021)

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Review Chemistry, Medicinal

Alzheimer's disease and its treatment by different approaches: A review

Sukriti Srivastava et al.

Summary: Alzheimer's disease is a neurodegenerative disorder that impairs mental ability development and interrupts neurocognitive function. Current treatments only provide symptomatic relief with no cure available yet. Nanotechnology and stem cell-based therapy are seen as promising approaches to overcome the obstacles in treating AD.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Piotr Tarach et al.

Summary: Carriers of genetic material can be viral or non-viral, with non-viral carriers like PAMAM dendrimers showing promise in gene therapy due to their unique physiochemical properties and modification strategies. However, regulatory issues and limitations in clinical translation still need to be addressed for their broad implementation. Further research and improvements are crucial for the development of PAMAM dendrimers as carriers of genetic material in anticancer gene therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

New Radionuclides and Technological Advances in SPECT and PET Scanners

Nicholas P. van der Meulen et al.

Summary: Advances in nuclear medicine are achieved through improvements in technology and radionuclides. These developments are intertwined and complementary based on different clinical questions, availability and need.

CANCERS (2021)

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Article Engineering, Biomedical

Nonviral gene delivery using PAMAM dendrimer conjugated with the nuclear localization signal peptide derived from human papillomavirus type 11 E2 protein

Jeil Lee et al.

Summary: PAMAM dendrimers are biocompatible polymers widely used in various biomedical applications. High-generation PAMAM dendrimers have high transfection efficiency but cause greater damage to membranous organelles. By modifying low-generation PAMAM G2 dendrimer, a new resin with low cytotoxicity suitable for gene therapy research can be obtained.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

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Review Pharmacology & Pharmacy

Modulating the Blood-Brain Barrier: A Comprehensive Review

Rory Whelan et al.

Summary: This review summarizes various classes of BBB modulators developed over the last five decades, discussing their recent advancements, advantages and disadvantages, while providing insight into their future as BBB modulators.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

RNA-Based Therapeutics: Current Developments in Targeted Molecular Therapy of Triple-Negative Breast Cancer

Sakib Haque et al.

Summary: Triple-negative breast cancer is a highly heterogeneous and aggressive cancer subtype with the highest mortality rate. Conventional treatments have been unsuccessful, leading to research efforts in developing new strategies. Targeted molecular therapy and RNA-based therapeutics are key areas of investigation for treating TNBC.

PHARMACEUTICS (2021)

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Article Optics

Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

Junrong Huang et al.

Summary: A rapid and convenient detection method for biogenic polyamines is proposed in this study, utilizing a highly responsive fluorescent sensor synthesized from tetraphenyl ethylene (TPE) conjugated pentiptycene, with good selectivity for spermine at sub-micromolar levels. This small organic molecular bio-indicator shows potential application in clinical practice for detecting spermine in artificial urine.

JOURNAL OF LUMINESCENCE (2021)

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Article Materials Science, Biomaterials

Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density

Ayako Tsujimoto et al.

Summary: This study explores the tripartite relationship among PEG density, hydration state, and passive tumor targeting property in PEGylated dendrimers. It is the first report to demonstrate the hydration state of a drug carrier and discuss its relationship with biodistribution. Fully PEGylated dendrimers exhibited similar hydration behavior to PEG and passive tumor targeting property, while partially PEGylated dendrimers showed different hydration behavior and lacked the passive tumor targeting property.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Sijin Chen et al.

Summary: This review summarized the advanced development in the synthesis and modification strategies of ε-poly-L-lysine (EPL) and lysine-based dendrimer (LBD) compounds, focusing on their applications in biomedical fields such as agents, adjuvants, and carriers for anti-pathogen, tumor, and gene therapies. The combination with other advanced methodologies and technologies shows potential for overcoming challenges like scale production and high expenses in the future development of lysine-based polymers.

FRONTIERS IN CHEMISTRY (2021)

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Review Oncology

microRNAs as Novel Therapeutics in Cancer

Giulia Romano et al.

Summary: miRNAs play crucial roles in gene regulation across various biological pathways, including cancer. Despite significant progress in understanding the molecular mechanisms affecting miRNAs in cancer, their translation into therapy remains in early stages due to limited delivery methods and concerns about toxicity. Advances in formulations and vectors have improved the stability and specificity of miRNA therapy, with ongoing clinical trials showing promising results for future applications in cancer treatment.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Next Step in Gene Delivery: Modern Approaches and Further Perspectives of AAV Tropism Modification

Maxim A. Korneyenkov et al.

Summary: AAV is a popular choice for gene therapy delivery, but its unspecific tissue tropism is a serious limitation. Recent techniques have been developed to produce highly selective and targeted AAV capsids, although it is still far from the ideal state. Despite drawbacks and limitations, other approaches are still in play in the field of AAV research.

PHARMACEUTICS (2021)

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Article Nanoscience & Nanotechnology

Dressing Blood-Contacting Materials by a Stable Hydrogel Coating with Embedded Antimicrobial Peptides for Robust Antibacterial and Antithrombus Properties

Kunpeng Liu et al.

Summary: A stable and antifouling hydrogel coating embedded with antimicrobial peptides (AMPs) was developed to possess remarkable antibacterial and antithrombus abilities. The coating showed good hemocompatibility, bactericidal properties, and anti-adhesion abilities against both Gram-positive and Gram-negative bacteria. Animal experiments confirmed its anti-infection performance and histological data indicated excellent anti-inflammatory function, suggesting promising applications in preventing bacterial infections and thrombosis in clinical settings.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biophysics

Triphenylamine-perylene diimide conjugate-based organic nanoparticles for photoacoustic imaging and cancer phototherapy

Haolan Li et al.

Summary: A new organic compound PIT with a typical D-A-D structure was designed and synthesized, and its NPs exhibited good water dispersibility, high photothermal conversion efficiency, and strong photoacoustic signal, inducing significant reactive oxygen species. These PIT NPs showed good biocompatibility and outstanding photocytotoxicity, making them excellent candidates for photoacoustic imaging and photodynamic/photothermal therapy.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Polymer Science

Poly (propylene imine) dendrimer as an emerging polymeric nanocarrier for anticancer drug and gene delivery

Vanshikha Singh et al.

Summary: Dendrimers are versatile nanocarriers capable of delivering drugs, antibodies, or therapeutic genes, with potential benefits in cancer therapy. Particularly, PPI dendrimers can be customized for targeted drug delivery to specific tumor sites, enhancing efficacy and reducing adverse effects.

EUROPEAN POLYMER JOURNAL (2021)

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Review Biochemistry & Molecular Biology

How Far Are Non-Viral Vectors to Come of Age and Reach Clinical Translation in Gene Therapy?

Myriam Sainz-Ramos et al.

Summary: This review highlights the critical importance of efficient delivery of genetic material into cells for translating gene therapy into clinical practice, with a focus on non-viral vector systems as a promising alternative to virus-based gene delivery. The challenges and potential strategies for clinical application of non-viral vectors in mainstream medicine, including efficiency, biocompatibility, and long-lasting effect, are discussed in order to promote safe and efficient non-viral gene delivery systems for clinical applications in the gene therapy field.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Medicinal

Noncovalent Interactions with PAMAM and PPI Dendrimers Promote the Cellular Uptake and Photodynamic Activity of Rose Bengal: The Role of the Dendrimer Structure

Krzysztof Sztandera et al.

Summary: In this study, interactions between rose bengal and cationic dendrimers were characterized at multiple levels in vitro and in silico, showing that dendrimers of the third and fourth generation can enhance the photosensitizing properties of the dye by increasing cellular uptake and production of reactive oxygen species. The results suggest that dendrimer carriers could facilitate the development of efficient photodynamic therapies using rose bengal.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

Dapeng Zhang et al.

Summary: Efficient delivery of nucleic acids is crucial for genetic nanomedicine. While viral vectors are highly efficient, they can also cause severe immune responses, toxicity, and mutations. Nonviral lipid nanoparticles containing specific components show promise for mRNA delivery, but challenges such as stability at low temperatures need to be addressed.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Pharmacology & Pharmacy

Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy

Yoonhee Bae et al.

Summary: The study focused on synthesizing PAMAMG3 derivatives for delivering the apoptin gene into glioma cells and fibroblasts. Results indicated that the PAMAMG3-HKRRR/apoptin complex could be a potential candidate for an effective nonviral gene delivery system for brain tumor therapy in vitro.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2021)

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Article Polymer Science

Impact of Changing the Core in Tetrapyrrolic Dendrimers Designed for Oxygen Sensitization: New Fluorescent Phthalocyanine-Based Dendrimers with High Two-Photon Absorption Cross-sections

Seifallah Abid et al.

Summary: By changing the central porphyrin core to a phthalocyanine core in macromolecular structures, new dendrimers with multiple conjugated endgroups were prepared and studied. Efficient energy transfer from peripheral units to central unit led to intense red light emission and oxygen photosensitization, while significantly boosting two-photon absorption cross-sections. The impact of this structural change was discussed in relation to dendrimer generations using DFT and molecular dynamic calculations.

MACROMOLECULES (2021)

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Review Chemistry, Analytical

Biomedical application of hyperbranched polymers: Recent Advances and challenges

Arezoo Saadati et al.

Summary: Hyperbranched polymers (HBPs) with special structures and applications are promising in various biomedical fields, including disease diagnosis, tissue engineering, and drug delivery. However, challenges in biocompatibility and toxicity still exist.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

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Article Engineering, Biomedical

Overcoming T Cell Exhaustion via Immune Checkpoint Modulation with a Dendrimer-Based Hybrid Nanocomplex

Yue Gao et al.

Summary: A novel dendrimer-based nanohybrid platform is developed for dual-mode CT/MR imaging-guided cancer immunotherapy by regulating T cell exhaustion, showing promising potential for overcoming immune escape of cancer cells and improving the efficiency of cancer immunotherapy.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Genetics & Heredity

Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy

Fereydoon Abedi Gaballu et al.

Summary: The study successfully delivered specific siRNA targeting HMGA2 using G4/MTX-siRNA nanocomplex, inducing apoptosis in breast cancer cells, suggesting a promising therapeutic strategy for breast cancer treatment.

GENES (2021)

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Article Chemistry, Multidisciplinary

A ROS and shear stress dual-sensitive bionic system with cross-linked dendrimers for atherosclerosis therapy

Meili Shen et al.

Summary: The study developed a dual-response drug delivery system for the treatment of atherosclerosis, which could release drugs in response to the special microenvironment of plaques and detach under shear stress stimulus. The system showed better therapeutic effects and excellent safety in vivo compared to free drugs, demonstrating its promising potential for atherosclerosis treatment.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

A dendrimer-functionalized turn-on fluorescence probe based on enzyme-activated debonding feature of azobenzene linkage

Bing-Yen Wang et al.

Summary: Hypoxia in tumors leads to overexpression of oxidoreductases, such as NQO1, which has been targeted for developing chemotherapeutic drugs. By grafting nonfluorescent coumarin probes onto PAMAM dendrimers and activating them through NQO1 recognition, a facile method for tumor diagnosis has been proposed. The results showed that AMC probes could be released from the dendrimers in A549 tumorspheres, indicating potential for bright fluorescence imaging.

NEW JOURNAL OF CHEMISTRY (2021)

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Article Materials Science, Biomaterials

The influence of modified molecular (d/l-serine) chirality on the theragnostics of PAMAM-based nanomedicine for acute kidney injury

Lulu Kong et al.

Summary: Acute kidney injury (AKI) is a severe clinical disease with high morbidity and mortality. Recent studies have shown that chiral molecule modification of nanomaterials is an effective strategy to regulate their biodistribution, which has been applied in the early detection and treatment of AKI with promising results.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

Multicompartment dendrimicelles with binary, ternary and quaternary core composition

Rebecca Kaup et al.

Summary: This study presents a versatile strategy to generate and characterize complex coacervate-core micelles using four different dendrimeric subcomponents as core-units. The study demonstrates the synchronous encapsulation of dendrimers in the micelle core using FRET technology, with optimal efficiency occurring at 70% loading. Chemical etching can restore FRET efficiency, showing the controlled co-assembly of different subcomponents and the wide variety of structures that can be created using a well-defined basic set of subcomponents.

NANOSCALE (2021)

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Review Chemistry, Multidisciplinary

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

Qinghua Wang et al.

Summary: With the increasing incidence of central nervous system diseases due to the aging population, delivering drugs into the CNS remains challenging because of the blood-brain barrier. Targeted delivery systems utilizing RVG peptide modified carriers can encapsulate a wide range of drugs to effectively treat various CNS diseases.

RSC ADVANCES (2021)

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Article Nanoscience & Nanotechnology

Lanthanide-Cyclen-Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging

Yonghong Zhang et al.

Summary: This study successfully achieved therapeutic efficacy in cancer cell selectivity by synthesizing lanthanide nanoparticles with hybrid near-infrared and magnetic resonance imaging properties.

ACS APPLIED NANO MATERIALS (2021)

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Article Materials Science, Biomaterials

Octadecyl chain-bearing PEGylated poly(propyleneimine)-based dendrimersomes: physicochemical studies, redox-responsiveness, DNA condensation, cytotoxicity and gene delivery to cancer cells

Partha Laskar et al.

Summary: Stimuli-responsive nanocarriers, specifically disulphide-linked, octadecyl chain-bearing PEGylated dendrimersomes, show stable and nanosized vesicles with redox-responsiveness, efficient gene delivery, enhanced gene expression and cellular uptake in prostate cancer cells, making them promising for combination cancer therapy applications.

BIOMATERIALS SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Nanoscale delivery systems for microRNAs in cancer therapy

Sanda Boca et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Review Pharmacology & Pharmacy

Dendrimers in the context of nanomedicine

Ana Paula Dias et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Nanoscience & Nanotechnology

In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor

Chaochao Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Specific Core-Satellite Nanocarriers for Enhanced Intracellular ROS Generation and Synergistic Photodynamic Therapy

Tingting Shen et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

Application of new lysine-based peptide dendrimers D3K2 and D3G2 for gene delivery: Specific cytotoxicity to cancer cells and transfection in vitro

Michal Gorzkiewicz et al.

BIOORGANIC CHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification

Qianru Yu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

Reverting chemoresistance of targeted agents by a ultrasoluble dendritic nanocapsule

Qida Hu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Biotechnology & Applied Microbiology

Immune Responses to Viral Gene Therapy Vectors

Jamie L. Shirley et al.

MOLECULAR THERAPY (2020)

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Review Chemistry, Physical

Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems

Claudia Sandoval-Yanez et al.

MATERIALS (2020)

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Article Multidisciplinary Sciences

Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders

Anjali Sharma et al.

SCIENCE ADVANCES (2020)

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Article Entomology

Efficient Delivery of dsRNA and DNA in Cultured Silkworm Cells for Gene Function Analysis Using PAMAM Dendrimers System

Chenchen Lu et al.

INSECTS (2020)

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Article Biochemistry & Molecular Biology

Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

Adriana Cruz et al.

ANTIOXIDANTS (2020)

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Article Biochemistry & Molecular Biology

Revisiting Cationic Phosphorus Dendrimers as a Nonviral Vector for Optimized Gene Delivery Toward Cancer Therapy Applications

Liang Chen et al.

BIOMACROMOLECULES (2020)

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Article Engineering, Biomedical

Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy

Shuang Liang et al.

BIOMATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Effective Elimination of Charge-associated Toxicity of Low Generation Polyamidoamine Dendrimer Eases Drug Delivery of Oxaliplatin

Vo Minh Hoang Do et al.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2020)

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Article Biophysics

Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells

Maryam Ghaffari et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Nanoscience & Nanotechnology

Biodegradable Polymers for Gene-Delivery Applications

Chih-Kuang Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

Transferrin Conjugated pH- and Redox-Responsive Poly(Amidoamine) Dendrimer Conjugate as an Efficient Drug Delivery Carrier for Cancer Therapy

Qing Hu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Pharmacology & Pharmacy

Mitochondrial delivery of microRNA mimic let-7b to NSCLC cells by PAMAM-based nanoparticles

Niloufar Maghsoudni et al.

JOURNAL OF DRUG TARGETING (2020)

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Article Chemistry, Multidisciplinary

3-Bromopyruvate-Conjugated Nanoplatform-Induced Pro-Death Autophagy for Enhanced Photodynamic Therapy against Hypoxic Tumor

Yongyan Deng et al.

ACS NANO (2020)

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Review Neurosciences

Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

Seetha Harilal et al.

BRAIN RESEARCH BULLETIN (2020)

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Review Biochemistry & Molecular Biology

The Role of the Liver-Specific microRNA, miRNA-122 in the HCV Replication Cycle

Rasika D. Kunden et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies

Alexis Forterre et al.

CANCERS (2020)

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Article Pharmacology & Pharmacy

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

Natalia Sanz del Olmo et al.

PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury

Rishi Sharma et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Analytical

Platinum nanozyme-encapsulated poly(amidoamine) dendrimer for voltammetric immunoassay of pro-gastrin-releasing peptide

Li-Juan Zhi et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Combining competitive sequestration with nonlinear hybridization chain reaction amplification: an ultra-specific and highly sensitive sensing strategy for single-nucleotide variants

Yan Zhao et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Biochemical Research Methods

Benzylguanidine and Galactose Double-Conjugated Chitosan Nanoparticles with Reduction Responsiveness for Targeted Delivery of Doxorubicin to CXCR 4 Positive Tumors

Fei Kong et al.

BIOCONJUGATE CHEMISTRY (2020)

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Review Pharmacology & Pharmacy

Role of the neurovascular unit in the process of cerebral ischemic injury

Yu Zhao et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Polymer Science

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Sabya Sachi Das et al.

POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Folate-Targeted Transgenic Activity of Dendrimer Functionalized Selenium Nanoparticles In Vitro

Nikita Simone Pillay et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Carbosilane dendrimers: Drug and gene delivery applications

Navid Rabiee et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI

Songbai Zhang et al.

PHARMACEUTICS (2020)

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Article Materials Science, Multidisciplinary

Tunable membrane-penetrating bioreductive nanogels based on guanidinylated dendrimers for programmable gene delivery

Jie Zhou et al.

APPLIED MATERIALS TODAY (2020)

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Article Chemistry, Multidisciplinary

Red-Fluorescent Pt Nanoclusters for Detecting and Imaging HER2 in Breast Cancer Cells

Shin-ichi Tanaka et al.

ACS OMEGA (2020)

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Review Chemistry, Multidisciplinary

Self-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(amidoamine) Dendrimers

Zhenbin Lyu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

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Article Biophysics

Self-assembly of methylene violet-conjugated perylene diimide with photodynamic/photothermal properties for DNA photocleavage and cancer treatment

Haolan Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Pharmacology & Pharmacy

In vivo therapeutic applications of phosphorus dendrimers: state of the art

Serge Mignani et al.

DRUG DISCOVERY TODAY (2020)

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Review Pharmacology & Pharmacy

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Sibusiso Alven et al.

PHARMACEUTICS (2020)

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Review Oncology

CD44 as a tumor biomarker and therapeutic target

Hanxiao Xu et al.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding et al.

CHEMICAL COMMUNICATIONS (2020)

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Review Materials Science, Biomaterials

Dendrimer nanoparticles for colorectal cancer applications

M. R. Carvalho et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Biochemistry & Molecular Biology

Fludarabine-Specific Molecular Interactions with Maltose-Modified Poly(propyleneimine) Dendrimer Enable Effective Cell Entry of the Active Drug Form: Comparison with Clofarabine

Michal Gorzkiewicz et al.

BIOMACROMOLECULES (2019)

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Article Engineering, Biomedical

Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy

Jun Xu et al.

BIOMATERIALS (2019)

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Article Pharmacology & Pharmacy

Biotin functionalized PEGylated poly(amidoamine) dendrimer conjugate for active targeting of paclitaxel in cancer

Vishnu Kiran Rompicharla et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Multidisciplinary Sciences

Upconversion amplification through dielectric superlensing modulation

Liangliang Liang et al.

NATURE COMMUNICATIONS (2019)

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Article Cell & Tissue Engineering

A novel approach to label bone marrow-derived mesenchymal stem cells with mixed-surface PAMAM dendrimers

Nikolas Munro et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Chemistry, Multidisciplinary

Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

Wei Tao et al.

ACS NANO (2019)

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Article Pharmacology & Pharmacy

Carbosilane dendrimers with phosphonium terminal groups are low toxic non-viral transfection vectors for siRNA cell delivery

Regina Herma et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Medicine, Research & Experimental

Drug-Conjugated Dendrimer Hydrogel Enables Sustained Drug Release via a Self-Cleaving Mechanism

Juan Wang et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Biochemistry & Molecular Biology

Behavioral and Biochemical Implications of Dendrimeric Rivastigmine in Memory-Deficit and Alzheimer's Induced Rodents

Avinash Gothwal et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Article Chemistry, Multidisciplinary

In Vivo Tumor Visualization through MRI Off-On Switching of NaGdF4-CaCO3 Nanoconjugates

Zhigao Yi et al.

ADVANCED MATERIALS (2019)

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Review Nanoscience & Nanotechnology

Recent expansions of novel strategies towards the drug targeting into the brain

Amit Alexander et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Pharmacology & Pharmacy

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers

Domenico Marson et al.

PHARMACEUTICS (2019)

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Review Biochemistry & Molecular Biology

Cytotoxicity of Dendrimers

Anna Janaszewska et al.

BIOMOLECULES (2019)

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Review Chemistry, Multidisciplinary

Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation

Angelo Homayoun All et al.

ADVANCED MATERIALS (2019)

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Article Biochemical Research Methods

Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer's Disease in Mice

Avinash Gothwal et al.

BIOCONJUGATE CHEMISTRY (2019)

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Article Engineering, Biomedical

Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging

Yuxin Han et al.

BIOMATERIALS (2019)

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Article Engineering, Biomedical

A pH-responsive platform combining chemodynamic therapy with limotherapy for simultaneous bioimaging and synergistic cancer therapy

Jianmin Xiao et al.

BIOMATERIALS (2019)

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Review Pharmacology & Pharmacy

Pharmacokinetics of oral therapeutics delivered by dendrimer-based carriers

Venkata K. Yellepeddi et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Biotechnology & Applied Microbiology

Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

Aleksandra Ellert-Miklaszewska et al.

NANOMEDICINE (2019)

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Article Biophysics

Organic small molecular nanoparticles based on self-assembly of amphiphilic fluoroporphyrins for photodynamic and photothermal synergistic cancer therapy

Lixia Yang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Chemistry, Multidisciplinary

Dendrimeric Nanoparticles for Two-Photon Photodynamic Therapy and Imaging: Synthesis, Photophysical Properties, Innocuousness in Daylight and Cytotoxicity under Two-Photon Irradiation in the NIR

Aude Sourdon et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

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Article Multidisciplinary Sciences

Reactivation of Epstein-Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function

Lijun Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Oncology

Long noncoding RNA LSINCT5 promotes endometrial carcinoma cell proliferation, cycle, and invasion by promoting the Wnt/β-catenin signaling pathway via HMGA2

Hongye Jiang et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2019)

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Article Pharmacology & Pharmacy

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Chen Xie et al.

ADVANCED THERAPEUTICS (2019)

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Article Chemistry, Multidisciplinary

A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation

Wangteng Wu et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Materials Science, Biomaterials

Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery

Yaqiang Wang et al.

BIOMATERIALS SCIENCE (2019)

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Review Engineering, Biomedical

Recent advances in the development of gene delivery systems

Y. K. Sung et al.

BIOMATERIALS RESEARCH (2019)

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Review Pathology

MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury

Lawrence S. Howell et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

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Article Chemistry, Inorganic & Nuclear

Reversible and Sensitive Hg2+ Detection by a Cell-Permeable Ytterbium Complex

Guochen Bao et al.

INORGANIC CHEMISTRY (2018)

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Review Nanoscience & Nanotechnology

Two decades of dendrimers as versatile MRI agents: a tale with and without metals

Michael T. McMahon et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Imaging Tiny Hepatic Tumor Xenografts via Endoglin-Targeted Paramagnetic/Optical Nanoprobe

Huihui Yan et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication

Wen Song et al.

ACS NANO (2018)

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Article Biochemistry & Molecular Biology

Glycodendrimer Nanocarriers for Direct Delivery of Fludarabine Triphosphate to Leukemic Cells: Improved Pharmacokinetics and Pharmacodynamics of Fludarabine

Michal Gorzkiewicz et al.

BIOMACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Evaluation of Amphiphilic Star/Linear-Dendritic Polymer Reverse Micelles for Transdermal Drug Delivery: Directing Carrier Properties by Tailoring Core versus Peripheral Branching

Karolina A. Kosakowska et al.

BIOMACROMOLECULES (2018)

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Article Nanoscience & Nanotechnology

Inhibition of cell proliferation and migration through nucleobase-modified polyamidoamine-mediated p53 delivery

Haobo Han et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Review Pharmacology & Pharmacy

Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy

Jun Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

Anjali Sharma et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Materials Science, Biomaterials

Biodegradable dendrimers for drug delivery

Da Huang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Chemistry, Multidisciplinary

Cu-64-Labeled multifunctional dendrimers for targeted tumor PET imaging

Wenhui Ma et al.

NANOSCALE (2018)

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Article Multidisciplinary Sciences

Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics

Shuo Chen et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

PEGylation of polypropylenimine dendrimers: effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells

Sukrut Somani et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Quantitative analysis of DNA with single-molecule sequencing

Takahito Ohshiro et al.

SCIENTIFIC REPORTS (2018)

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Article Biotechnology & Applied Microbiology

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization

Elena Sanchez-Lopez et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Construction of Hyaluronic Tetrasaccharide Clusters Modified Polyamidoamine siRNA Delivery System

Yingcong Ma et al.

NANOMATERIALS (2018)

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Article Chemistry, Multidisciplinary

Enhanced Delivery of Therapeutic siRNA into Glioblastoma Cells Using Dendrimer-Entrapped Gold Nanoparticles Conjugated with β-Cyclodextrin

Jieru Qiu et al.

NANOMATERIALS (2018)

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Article Chemistry, Multidisciplinary

Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates

Pierpaolo Moscariello et al.

ADVANCED SCIENCE (2018)

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Review Polymer Science

Precisely Defined Polymers for Efficient Gene Delivery

Dongsheng He et al.

POLYMERIC GENE DELIVERY SYSTEMS (2018)

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Article Chemistry, Applied

Hyaluronic acid-functionalized half-generation of sectorial dendrimers for anticancer drug delivery and enhanced biocompatibility

Xiao Du et al.

CARBOHYDRATE POLYMERS (2018)

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Article Nanoscience & Nanotechnology

Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers

Carola Diaz et al.

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NANOSCALE (2018)

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Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

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NANOSCALE (2018)

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All-inorganic perovskite nanocrystal scintillators

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Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression

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MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2018)

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Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

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PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

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JOURNAL OF CONTROLLED RELEASE (2018)

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Precisely Defined Polymers for Efficient Gene Delivery

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TOPICS IN CURRENT CHEMISTRY (2018)

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Review Materials Science, Multidisciplinary

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

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APPLIED MATERIALS TODAY (2018)

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Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Targeting human liver cancer cells with lactobionic acid-G(4)-PAMAM-FITC sorafenib loaded dendrimers

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations

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JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Review Biochemistry & Molecular Biology

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

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Binary temporal upconversion codes of Mn2+-activated nanoparticles for multilevel anti-counterfeiting

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NATURE COMMUNICATIONS (2017)

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AS1411 Aptamer-Anionic Linear Globular Dendrimer G2-Iohexol Selective Nano-Theranostics

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Design, Synthesis, and Surface Modification of Materials Based on Transition-Metal Dichalcogenides for Biomedical Applications

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A Combination of Guanidyl and Phenyl Groups on a Dendrimer Enables Efficient siRNA and DNA Delivery

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A luminescent lanthanide approach towards direct visualization of primary cilia in living cells

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Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery

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Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis

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Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery

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DRUG DISCOVERY TODAY (2017)

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Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain

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Fourier transform infrared spectroscopy (FTIR) characterization of the interaction of anti-cancer photosensitizers with dendrimers

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ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2016)

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Tailoring the dendrimer core for efficient gene delivery

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ACTA BIOMATERIALIA (2016)

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Designing Upconversion Nanocrystals Capable of 745 nm Sensitization and 803 nm Emission for Deep-Tissue Imaging

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CHEMISTRY-A EUROPEAN JOURNAL (2016)

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Conjugation to Poly(amidoamine) Dendrimers and Pulmonary Delivery Reduce Cardiac Accumulation and Enhance Antitumor Activity of Doxorubicin in Lung Metastasis

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MOLECULAR PHARMACEUTICS (2016)

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Editorial Material Biotechnology & Applied Microbiology

Personalized medicine: the enabling role of nanotechnology

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NANOMEDICINE (2016)

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Self-Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery

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PAMAM dendrimers as promising nanocarriers for RNAi therapeutics

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Glycodendrimers and Modified ELISAs: Tools to Elucidate Multivalent Interactions of Galectins 1 and 3

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MOLECULES (2015)

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Perylenediimide-cored dendrimers and their bioimaging and gene delivery applications

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PROGRESS IN POLYMER SCIENCE (2015)

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Multifunctional Lactobionic Acid-Modified Dendrimers for Targeted Drug Delivery to Liver Cancer Cells: Investigating the Role Played by PEG Spacer

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ACS APPLIED MATERIALS & INTERFACES (2014)

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Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling

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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2013)

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The Possible Proton Sponge Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

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Mitochondrially targeted compounds and their impact on cellular bioenergetics

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REDOX BIOLOGY (2013)

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Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex

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Polyphosphonium Polymers for siRNA Delivery: An Efficient and Nontoxic Alternative to Polyammonium Carriers

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

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Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA

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JOURNAL OF PEPTIDE SCIENCE (2011)

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Remnant cationic dendrimers block RNA migration in electrophoresis after monophasic lysis

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Dendrimers: Novel polymeric nanoarchitectures for solubility enhancement

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Convergent synthesis of internally branched PAMAM dendrimers

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ORGANIC LETTERS (2005)

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