期刊
SLEEP AND BREATHING
卷 27, 期 3, 页码 1027-1032出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11325-022-02699-8
关键词
Heart failure; Central sleep apnea; Phrenic nerve stimulation
This study explored the effectiveness of phrenic nerve stimulation (PNS) on central sleep apnea (CSA) in heart failure patients. The results showed that PNS treatment significantly decreased the apnea-hypopnea index and increased mean arterial oxygen saturation. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea.
Objective Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF. Methods This was a prospective and non-randomized study. The stimulation lead was inserted into the right brachiocephalic vein and attached to a proprietary neurostimulator. Monitoring was conducted during the implantation process, and all individuals underwent two-night polysomnography. Results A total of nine subjects with HF and CSA were enrolled in our center. There was a significant decrease in the apnea-hypopnea index (41 +/- 18 vs 29 +/- 25, p = 0.02) and an increase in mean arterial oxygen saturation (SaO2) (93% +/- 1% vs 95% +/- 2%, p = 0.03) after PNS treatment. We did not observe any significant differences of oxygen desaturation index (ODI) and SaO2 < 90% (T90) following PNS. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea. Conclusion In our non-randomized study, PNS may serve as a therapeutic approach for CSA in patients with HF.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据