☆ 4.6 Review

REGULATORY ROLE OF NONCODING RNA IN SEPSIS AND SEPSIS-ASSOCIATED ORGAN DYSFUNCTION: AN UPDATED SYSTEMATIC REVIEW

SHOCK (2022)

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Article Neurosciences

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis

Xue-biao Wei et al.

Summary: This study found that sepsis can cause severe sepsis-associated encephalopathy (SAE) and exacerbate the disease by promoting ferroptosis. The blood-brain barrier is damaged, leading to the accumulation of iron ions in the brain, oxidative stress, and ultimately cell death. NEAT1 in exosomes enhances ferroptosis stress by regulating the miR-9-5p/TFRC and GOT1 axis, further exacerbating sepsis-associated encephalopathy.

MOLECULAR NEUROBIOLOGY (2022)

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Article Medicine, Research & Experimental

Effects and early diagnostic value of lncRNA H19 on sepsis-induced acute lung injury

Y. O. U. ZHOU et al.

Summary: This study found that lncRNA H19 is downregulated in sepsis patients. Upregulating lncRNA H19 can inhibit the inflammatory response and cellular apoptosis induced by sepsis, and has value in the early diagnosis of sepsis.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis

JinFang Ke et al.

Summary: This study revealed that circVMA21 improves sepsis-induced lung injury by targeting the miR-497-5p/CD2AP axis, suggesting that circVMA21 may serve as a novel therapeutic target for sepsis-induced lung injury.

BIOENGINEERED (2022)

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Article Biochemistry & Molecular Biology

LncRNA NORAD deficiency alleviates kidney injury in mice and decreases the inflammatory response and apoptosis of lipopolysaccharide-stimulated HK-2 cells via the miR-577/GOLPH3 axis

Zhijuan Xie et al.

Summary: The study demonstrated that NORAD knockdown alleviates kidney injury in mice and reduces inflammation and apoptosis of LPS-stimulated HK-2 cells via the miR-577/GOLPH3 axis.

CYTOKINE (2022)

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Article Medicine, General & Internal

circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury

Jiang Zhu et al.

Summary: The study demonstrates that circ_0001679 knockdown inhibits sepsis-induced acute lung injury (ALI) progression via the miR-338-3p/DUSP16 axis.

OPEN MEDICINE (2022)

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Article Medicine, Research & Experimental

Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1

Min Gao et al.

Summary: The study investigated the effect of miR-1-3p on endothelial cells during sepsis, finding that miR-1-3p inhibits cell proliferation, promotes apoptosis and cytoskeleton contraction by targeting SERP1, leading to dysfunction of endothelial cells and weakening vascular barrier function. MiR-1-3p and SERP1 may be promising therapeutic candidates for sepsis-induced lung injury.

CLINICAL SCIENCE (2021)

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Article Gastroenterology & Hepatology

Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function

Lan Xiao et al.

Summary: Results from studies on mice, intestinal epithelial cells, and human tissues suggest that circHIPK3 improves repair of the intestinal epithelium by reducing miR-29b availability.

GASTROENTEROLOGY (2021)

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Article Biophysics

Circ-BNIP3L knockdown alleviates LPS-induced renal tubular epithelial cell injury during sepsis-associated acute kidney injury by miR-370-3p/MYD88 axis

Yanyan Zhou et al.

Summary: This study investigated the role of circular RNA circ-BNIP3L in sepsis-associated acute kidney injury (SA-AKI) and found that circ-BNIP3L regulates renal tubular epithelial cell injury through the miR-370-3p/MYD88 axis, providing a new avenue for the treatment of sepsis-associated AKI.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2021)

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Article Urology & Nephrology

Deregulated microRNA-22-3p in patients with sepsis-induced acute kidney injury serves as a new biomarker to predict disease occurrence and 28-day survival outcomes

Hui Zhang et al.

Summary: The expression of miR-22-3p was decreased in sepsis-induced AKI patients and negatively correlated with kidney injury biomarkers. MiR-22-3p served as a risk factor for AKI onset, had diagnostic accuracy in septic AKI patients, and served as a prognostic biomarker to predict 28-day survival in septic AKI patients.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)

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Article Oncology

lncRNA PVT1 modulates NLRP3-mediated pyroptosis in septic acute kidney injury by targeting miR-20a-5p

Long-Tian Deng et al.

Summary: This study demonstrated the mechanism of PVT1 in regulating pyroptosis in septic AKI, suggesting potential therapeutic targets for septic AKI.

MOLECULAR MEDICINE REPORTS (2021)

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Article Cell Biology

LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1a/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury

Hua Ling et al.

Summary: In sepsis-induced renal injury, GAS5 and miR-579-3p play crucial roles in regulating cell pyroptosis. GAS5 negatively regulates miR-579-3p to reduce cell pyroptosis by activating the SIRT1/PGC-1a/Nrf2 pathway.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

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Review Biochemical Research Methods

Non-coding RNA in cancer

Huiwen Yan et al.

Summary: The majority of the human genome is transcribed into non-coding RNAs (ncRNAs) that play crucial roles in regulating cancer initiation and progression. This review focuses on recent studies of the function, regulatory mechanisms, and therapeutic potential of ncRNAs such as microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), and PIWI interacting RNA (piRNA) in various types of cancers.

NON-CODING GENOME (2021)

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Review Medicine, Research & Experimental

Long non-coding RNA: An immune cells perspective

Salman Khan et al.

Summary: Long non-coding RNAs (lncRNAs) were once seen as genetic waste but are now recognized as important regulators of gene expression. Research has shown that lncRNAs play a key role in shaping immune cell function and response to disease, offering potential therapeutic targets for various illnesses.

LIFE SCIENCES (2021)

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Article Immunology

lncRNA Mirt2 upregulates miR-1246 through methylation to suppress LPS-induced lung cell apoptosis

Xuwen Xu et al.

Summary: This study revealed that Mirt2 expression was downregulated in sepsis and further decreased in patients with sepsis-ALI. Mirt2 may upregulate miR-1246 through methylation to suppress lung cell apoptosis.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Article Infectious Diseases

LncRNA ZFAS1 plays a role in regulating the inflammatory responses in sepsis-induced acute lung injury via mediating miR-193a-3p

Yan Jiang et al.

Summary: The overexpression of ZFAS1 significantly improved the inflammatory responses in sepsis-induced ALI rats, possibly by inhibiting apoptosis and promoting levels of proinflammatory cytokines.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Cardiac & Cardiovascular Systems

MiR-210-3p Enhances Cardiomyocyte Apoptosis and Mitochondrial Dysfunction by Targeting the NDUFA4 Gene in Sepsis-Induced Myocardial Dysfunction

Dandan Chen et al.

Summary: This study aimed to investigate the roles of miR-210-3p in regulating cardiomyocyte apoptosis and mitochondrial dysfunction associated with sepsis-induced myocardial dysfunction (SIMD) pathogenesis. The results showed that miR-210-3p promoted SIMD by targeting NDUFA4 to enhance cardiomyocyte apoptosis and impair mitochondrial function, and the expression of miR-210-3p was greatly increased in myocardial tissues of septic rats and septic serum-treated H9C2 cells.

INTERNATIONAL HEART JOURNAL (2021)

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Article Medicine, Research & Experimental

The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis

Xin Wang et al.

Summary: The study demonstrates that XIST, miR-150-5p, and c-Fos play crucial roles in regulating sepsis-induced myocardial injury via the TXNIP pathway. Silencing of XIST may provide a novel therapeutic strategy for improving cardiac function and reducing apoptosis and pyroptosis in septic rats. The XIST/miR-150-5p/c-Fos axis could be a potential target for the treatment of sepsis-induced myocardial injury.

LABORATORY INVESTIGATION (2021)

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Article Multidisciplinary Sciences

Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis

Chang Tian et al.

Summary: The study identified potential diagnostic markers for sepsis by analyzing the differential expression of circRNAs in serum exosomes, with hsa_circRNA_104484 and hsa_circRNA_104670 showing promise as novel diagnostic biomarkers.

SCIENTIFIC REPORTS (2021)

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Article Health Care Sciences & Services

Silencing of LncRNA-PVT1 ameliorates lipopolysaccharide-induced inflammation in THP-1-derived macrophages via inhibition of the p38 MAPK signaling pathway

Shengcai Zheng et al.

Summary: The study demonstrated that lncRNA-PVT1 plays a crucial role in the inflammatory response of sepsis through the p38 MAPK signaling pathway, and it can regulate its own expression through a positive feedback loop, providing a potential therapeutic target for LPS-induced inflammation.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Clinical value of microRNA-378a-3p in sepsis and its role in sepsis-induced inflammation and cardiac dysfunction

Qing Wang et al.

Summary: This study demonstrated that miR-378a-3p may serve as a potential diagnostic biomarker for sepsis, and lowering its levels could ameliorate cardiac dysfunction and inflammatory response caused by sepsis.

BIOENGINEERED (2021)

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Article Medicine, Research & Experimental

Clinical value and role of microRNA-29c-3p in sepsis-induced inflammation and cardiac dysfunction

Bingyu Zhang et al.

Summary: This study found that miR-29c-3p is upregulated in sepsis patients and can distinguish sepsis patients from healthy controls. In a rat sepsis model, cardiac dysfunction and inflammation were observed, but these effects were reversed by injecting miR-29c-3p antagomir. Logistic regression analysis indicated that miR-29c-3p is an independent factor in the occurrence of cardiac dysfunction in sepsis patients.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2021)

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Article Oncology

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

David S. Hong et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Cell Biology

Downregulation of lncRNA NEAT1 Ameliorates LPS-Induced Inflammatory Responses by Promoting Macrophage M2 Polarization via miR-125a-5p/TRAF6/TAK1 Axis

Wei Wang et al.

INFLAMMATION (2020)

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Article Biology

Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response

Bin Sun et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2020)

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Article Medical Laboratory Technology

Long noncoding RNA NEAT 1 and its target microRNA-125a in sepsis: Correlation with acute respiratory distress syndrome risk, biochemical indexes, disease severity, and 28-day mortality

Yongkai Yang et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Medicine, Research & Experimental

Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis

Zhiwen Liu et al.

THERANOSTICS (2020)

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Article Biochemistry & Molecular Biology

Silence of long noncoding RNA NEAT1 exerts suppressive effects on immunity during sepsis by promoting microRNA-125-dependent MCEMP1 downregulation

Jian-Xin Chen et al.

IUBMB LIFE (2019)

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Article Medical Laboratory Technology

Circulating lncRNA ITSN1-2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients

Qingwei Zeng et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2019)

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Article Critical Care Medicine

MIRNA-214 PROTECTS SEPSIS-INDUCED MYOCARDIAL INJURY

Chen Ge et al.

SHOCK (2018)

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Article Medicine, General & Internal

AAV5-Factor VIII Gene Transfer in Severe Hemophilia A

Savita Rangarajan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Critical Care Medicine

The involvement of regulatory non-coding RNAs in sepsis: a systematic review

Jeffery Ho et al.

CRITICAL CARE (2016)

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Article Critical Care Medicine

Two Decades of Mortality Trends Among Patients With Severe Sepsis: A Comparative Meta-Analysis

Elizabeth K. Stevenson et al.

CRITICAL CARE MEDICINE (2014)

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