期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 368, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2022.132098
关键词
Sulfur dioxide; NIR; Cell membrane targeting; In vivo imaging
资金
- Program for the Innovative Talents of Higher Education Institutions of Shanxi [2019L0937, 2019L0941, 2021L568]
- Applied Basic Research Programs of Shanxi Province [201801D221106, 20210302124012, 20210302124072]
- Lvliang Development Zones plan to introduce high-level scientific and technological talents [2017011-01, 2019105, 2019108]
- Scientific Instrument Center of Shanxi University [201512]
The comprehensive understanding of the mechanism between gas messenger molecules and cell membrane microenvironment is important for basic biology research. In this study, a ratiometric probe CMCB based on coumarin and indole sulfonate platform was designed and synthesized, which showed good targeting and near-infrared emission on cell membranes. The probe exhibited low detection limit, high selectivity, and specificity for targeting cell membranes.
The comprehensive understanding of the mechanism between gas messenger molecules and cell membrane microenvironment is of great significance for basic biology research. Sulfur dioxide (SO2), as a vital gas molecule, is of great value in the permeability and fluidity of cell membranes. However, monitoring of sulfur dioxide in cell membranes with high temporal and spatial resolution remains a challenge. Herein, we designed and synthesized a ratiometric probe CMCB based on coumarin and indole sulfonate platform. The unsaturated C--C is selected as the reaction site of SO2, utilizing sulfonic acid groups to increase CMCB hydrophilicity to achieve efficient targeting of cell membranes. The probe CMCB features a good cells membranes targeting and a NIR emission (720 nm). Interestingly, the probe showed low detection limit, high selectivity and specificity of targeting cell membranes. We expect that this probe will serve as an ideal tool in studying gas messenger molecule on cytomembrane in vivo.
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