期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 371, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2022.132613
关键词
Hollow-core anti-resonant optical fiber; Strong light-matter interaction; Multiplexed quantitative analysis; Enhanced sensitivity
资金
- National Natural Science Foundation of China
- National Research and Development Program of China
- Bei-jing Natural Science Foundations
- [92053116]
- [62035002]
- [2017YFB0405200]
- [L182011]
- [4192013]
The combination of non-touching hollow core anti-resonant fiber (HARF) and graphene oxide (GO) allows for the ultrasensitive and simultaneous quantification of multiple hazardous antibiotics in environmental samples, offering great potential for biomedical analysis.
Hollow-core fibers with special micro-geometry have been heralded for years as a supreme medium for data transmission, quantum communications and laser power delivery, owing to their low loss in the air-guiding structure. The recent advances of non-touching hollow core anti-resonant fiber (HARF) have further mini-mized the loss and improved the modal properties. Here we exploit biochemical sensing performance of HARF. We address hybridization of state-of-the-art HARF with graphene oxide (GO) to achieve strong light-matter interaction and enable ultrasensitive and simultaneous quantification of multiple hazardous antibiotics in environmental samples. The GO-HARF shows a strict light confinement in the core region with 8 dB/km attenuation at 600 nm wavelength via numerical simulation. The broadband transmission (400-1000 nm) of GO-HARF allows simultaneous fluorescence signal acquisition at multiple wavelengths. The operating principle relies on detecting dose-dependent fluorescence changes in GO-HARF when an antibiotics complex is streamed through the fiber channel. Over three-orders-of-magnitude enhancement of sensitivity is achieved with the GO-HARF sensor compared with the limit of detection (LoD) of a microplate reader. GO-HARF offers a unique opportu-nity to measure picomolar analytes at multiplexed wavelengths in the visible spectral range, holding great po-tential for fast-response, ultrasensitive and low-cost biomedical analyses.
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