4.6 Article

Reliability of the In Silico Prediction Approach to In Vitro Evaluation of Bacterial Toxicity

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SENSORS
卷 22, 期 17, 页码 -

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MDPI
DOI: 10.3390/s22176557

关键词

protein; toxin; virulence factors; BERT

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  1. Korea Environment Industry & Technology Institute (KEITI) through the Technology Development Project for Biological Hazards Management - Korea Ministry of Environment (MOE) [2021003380003]

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The toxicity of bacteria in indoor air is important to consider, and deep learning technology can help predict it.
Several pathogens that spread through the air are highly contagious, and related infectious diseases are more easily transmitted through airborne transmission under indoor conditions, as observed during the COVID-19 pandemic. Indoor air contaminated by microorganisms, including viruses, bacteria, and fungi, or by derived pathogenic substances, can endanger human health. Thus, identifying and analyzing the potential pathogens residing in the air are crucial to preventing disease and maintaining indoor air quality. Here, we applied deep learning technology to analyze and predict the toxicity of bacteria in indoor air. We trained the ProtBert model on toxic bacterial and virulence factor proteins and applied them to predict the potential toxicity of some bacterial species by analyzing their protein sequences. The results reflect the results of the in vitro analysis of their toxicity in human cells. The in silico-based simulation and the obtained results demonstrated that it is plausible to find possible toxic sequences in unknown protein sequences.

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