Targeting lactate-related cell cycle activities for cancer therapy

Article Oncology

Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer

Luigi Ippolito et al.

Summary: This research reveals that lactate can promote lipid metabolism in prostate cancer cells through the regulation of gene expression, thus contributing to cancer progression and metastasis.

CANCER RESEARCH (2022)

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Article Endocrinology & Metabolism

Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult

Prabhas Chaudhari et al.

Summary: Lactate acts through GPR81 to participate in brain angiogenesis and attenuate hypoxic/ischemic injury.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

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Article Biochemistry & Molecular Biology

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

Kun Yang et al.

Summary: High levels of lactate and HMGB1 are associated with the severity and mortality of sepsis. Lactate can promote HMGB1 lactylation and acetylation in macrophages, leading to HMGB1 release and increased endothelium permeability. Targeting lactate-associated signaling pathways may offer a potential strategy to combat sepsis.

CELL DEATH AND DIFFERENTIATION (2022)

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Review Cell Biology

Lactylation: a Passing Fad or the Future of Posttranslational Modification

Qi Xin et al.

Summary: This review summarizes recent advances in lactylation in lactate metabolism and diseases. Lactylation plays a vital role in cancer, inflammation, and regeneration, but the specific mechanism is still unclear. Histone lactylation regulates oncogenic processes and inflammation through gene transcription and macrophage activation.

INFLAMMATION (2022)

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Article Biochemistry & Molecular Biology

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Jia Xiong et al.

Summary: The lactylation-driven METTL3-mediated RNA m(6)A modification plays an important role in promoting the immunosuppressive capacity of tumor-infiltrating myeloid cells (TIMs).

MOLECULAR CELL (2022)

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Article Biochemistry & Molecular Biology

Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage

Haibin Deng et al.

Summary: The study reveals the crucial role of lactate dehydrogenase B (LDHB) in regulating glucose and mitochondrial metabolism, and its impact on the survival and proliferation of non-small cell lung cancer (NSCLC) cells.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Dendritic Cell-Based Immunotherapy in Hot and Cold Tumors

Byeong Hoon Kang et al.

Summary: Dendritic cells play a crucial role in immune responses and can activate cytotoxic T lymphocytes to kill tumor cells. Dendritic cell-based cancer immunotherapy has clinical benefits, but the immunogenicity and heterogeneity of tumors affect the success of this therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells

Yahui Wang et al.

Summary: This study found that the lactate excretion in proliferating cells is correlated with the activity of mitochondrial NADH shuttles, rather than proliferation itself. Proliferating cells primarily transform glucose to lactate when glycolysis outpaces the mitochondrial NADH shuttles.

MOLECULAR CELL (2022)

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Article Multidisciplinary Sciences

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Takahiro Seki et al.

Summary: Exposure to cold conditions inhibits the growth of various types of solid tumors by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells. Cold exposure also reduces glucose uptake in tumor tissue. These findings provide a new concept and paradigm for cancer therapy using a simple and effective approach.

NATURE (2022)

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Article Multidisciplinary Sciences

Identification of lysine-lactylated substrates in gastric cancer cells

Dawei Yang et al.

Summary: Cancer cells utilize aerobic glycolysis to promote lysine lactylation, a post-translational modification that plays a crucial role in gene expression regulation. Lactylated proteins are more abundant in gastric tumors and high levels of lysine lactylation are associated with poor prognosis, making it a potential prognostic marker for gastric cancer.

ISCIENCE (2022)

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Article Biochemistry & Molecular Biology

A combined metabolomics and molecular biology approach to reveal hepatic injury and underlying mechanisms after chronic L-lactate exposure in mice

Minjian Dong et al.

Summary: This study aimed to investigate the effects of chronic (L)-lactate exposure on peripheral tissues in mice and the underlying pathogenesis. The results revealed that chronic (L)-lactate exposure caused hepatocyte dysfunction in mice through increased oxidative stress and apoptosis.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

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Article Dentistry, Oral Surgery & Medicine

Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inhibition in vitro

Gregor Brandstetter et al.

Summary: The study suggests that inhibition of MCT, especially MCT4, may help overcome radiation resistance in tumor cell lines. Experimental results show that MCT inhibitors have significant impacts on cell growth, migration, and cell viability after radiation therapy.

CLINICAL ORAL INVESTIGATIONS (2021)

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Article Cell Biology

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

Jing Liu et al.

Summary: Glucose metabolism in mammalian cells varies with different cell cycle phases, with TCA cycle being predominantly used in G1 phase and glycolysis favored in S phase. The coupling of cell cycle with metabolism is largely achieved through Skp2-mediated timely destruction of key TCA cycle enzymes IDH1/2. This mechanistic link between aberrant cell cycle and glycolysis addiction provides insights into the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells.

CELL RESEARCH (2021)

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Article Oncology

Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes

Tianyu Zheng et al.

Summary: CREB1 is a transcription factor that responds to cAMP levels and controls the expression of target genes, regulating nutrition partitioning. While it plays an essential role in promoting tumor development, the full gene network constitutively regulated by CREB1 in tumors remains unrevealed. However, the known genes constitutively regulated by CREB1 in tumors are implicated in promoting tumorigenesis.

CANCER CELL INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Lactate Suppresses Retroviral Transduction in Cervical Epithelial Cells through DNA-PKcs Modulation

Waldemar Wagner et al.

Summary: The study reveals that lactate can decrease lentiviral transduction efficiency by increasing the nuclear localization of DNA-PKcs, and the stimulation of cells with HCA1 agonist or HDAC inhibitor can mimic this effect. Additionally, inhibiting lactate flux can also reduce the nuclear localization of DNA-PKcs, leading to diminished lentiviral transduction efficacy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter

Shivendra Vikram Singh et al.

Summary: This study explores the impact of MCT4 mediated extracellular acidosis on the efficacy of chemotherapeutic drugs on cancer cells. The acidic environment caused by altered glucose metabolism interferes with drug uptake and efficacy, but modulation of pH(e) enhances drug cytotoxicity. Inhibition of MCT4 or use of pH neutralizing agents may help overcome the impairment of drug efficacy due to pH changes.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Review Pharmacology & Pharmacy

Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)

Masaki Kobayashi et al.

Summary: The human monocarboxylate transporters hMCT1 and hMCT4 are involved in the transport of monocarboxylates such as L-lactate, playing essential roles in cellular metabolism and pH regulation. Overexpression of hMCT1 and hMCT4 in cancers, along with their association with cancer prognosis, has led to recent focus on inhibiting these transporters as a novel therapeutic strategy.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Biochemistry & Molecular Biology

The cancer metabolic reprogramming and immune response

Longzheng Xia et al.

Summary: The overlapping metabolic reprogramming between cancer and immune cells is an important factor affecting the antitumor immune response, involving metabolic competition, nutrient limitation, and impaired immune cell function. Studies have shown that metabolic reprogramming is essential for maintaining immune cell homeostasis and executing effector functions during immune responses.

MOLECULAR CANCER (2021)

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Article Multidisciplinary Sciences

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

Roberta Zappasodi et al.

Summary: By blocking CTLA-4, metabolic fitness and immune cell infiltration in tumours, especially those with low glycolytic activity, can be enhanced. This improves therapeutic outcomes, particularly in tumours with defective glycolysis, by destabilizing T-reg cells and promoting the activity of tumour-specific CD8(+) T cells.

NATURE (2021)

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Article Multidisciplinary Sciences

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson et al.

Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.

NATURE (2021)

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Review Oncology

Glycolysis-induced drug resistance in tumors-A response to danger signals?

Fabrizio Marcucci et al.

Summary: Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism, leading to drug resistance. Glycolysis-induced drug resistance may involve inhibition of apoptosis, induction of epithelial-mesenchymal transition, among other mechanisms.

NEOPLASIA (2021)

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Article Biochemistry & Molecular Biology

Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors

Anna-Lena Kopnick et al.

Summary: Monocarboxylate transporter isoforms play a crucial role in proton-coupled transport of l-lactate, potentially offering promising targets for anticancer therapy. This study identified Cys159 as a critical binding site for the inhibitory effects of pCMBS on MCT1 and provided insights into the mechanism of action.

FEBS JOURNAL (2021)

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Article Multidisciplinary Sciences

Cell-programmed nutrient partitioning in the tumour microenvironment

Bradley Reinfeld et al.

Summary: The study found that in the tumor microenvironment, different cell types have varying abilities to access and consume glucose and glutamine, with nutrient partitioning being programmed in a cell-intrinsic manner through mTORC1 signaling and the expression of genes related to glucose and glutamine metabolism.

NATURE (2021)

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Article Oncology

Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells

Zhen Liu et al.

Summary: The study showed that HSPA8 is overexpressed in imatinib-resistant CML cells and its ablation can inhibit cell proliferation, induce autophagy, and enhance the anti-tumor activity of imatinib. These findings reveal the role of HSPA8 in IR-CML and suggest its potential as a target for treatment.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Agriculture, Multidisciplinary

Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains

Xiaoxi Meng et al.

Summary: Protein lysine lactylation in rice is a novel post-translational modification that is enriched in proteins related to central carbon metabolism and protein biosynthesis, as well as frequently targeting nutrition reservoir proteins in rice grains. The study provides a comprehensive profile of lysine lactylation in cereal crop grains, indicating potential cross-talks with other acylations.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Meeting Abstract Oncology

Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).

Sarah E. R. Halford et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin

Shaomeng Chen et al.

Summary: This study demonstrates the synergistic effects of lactate/GPR81 blockade and metformin in inhibiting cancer cell growth, as well as enhancing immune cell functions and impacting PD-1 expression. The dual blockade strategy significantly enhances the anti-tumor effects of metformin, potentially leading to tumor regression.

BIOMOLECULES (2021)

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Review Hematology

A Clinical Triad with Fatal Implications: Recrudescent Diffuse Large B-cell Non-Hodgkin Lymphoma Presenting in the Leukemic Phase with an Elevated Serum Lactic Acid Level and Dysregulation of the TP53 Tumor Suppressor Gene - A Case Report and Literature Review

Catherine S. Hwang et al.

Summary: Despite being rare, DLBCL presenting with leukemic features, TP53 gene dysregulation, and elevated lactic acid levels indicates a poor prognosis. These features may be related to differential expressions of adhesion molecules on cell surfaces.

CLINICAL MEDICINE INSIGHTS-BLOOD DISORDERS (2021)

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Article Oncology

Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer

Zhe Zhao et al.

Summary: This study revealed that lung cancer patients with different gut microbiome compositions and microbiome metabolic pathways have varying responses to chemotherapy. Microbiome species are also associated with different lung cancer clinical phenotypes.

THORACIC CANCER (2021)

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Article Biochemistry & Molecular Biology

A lactate-induced Snail/STAT3 pathway drives GPR81 expression in lung cancer cells

Qiang Xie et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Article Biochemistry & Molecular Biology

Genome-Wide Characterization and Gene Expression Analyses of GATA Transcription Factors in Moso Bamboo (Phyllostachys edulis)

Taotao Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A

Anders Friberg et al.

ACS OMEGA (2020)

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Article Multidisciplinary Sciences

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Eman Khatib-Massalha et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia

Haizhi Yu et al.

CANCER COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

Ricardo A. Irizarry-Caro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

Youbo Zhao et al.

CELL REPORTS (2020)

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Article Endocrinology & Metabolism

Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade

Linpeng Li et al.

NATURE METABOLISM (2020)

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Review Biochemistry & Molecular Biology

Combination therapies with HSP90 inhibitors against colorectal cancer

Kushtrim Kryeziu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Review Medicine, Research & Experimental

Structural insights on druggable hotspots in CD147: A bull's eye view

Dhivya Kumar et al.

LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

Weina Zhang et al.

CELL (2019)

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Review Oncology

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB

Derya Kabacaoglu et al.

CANCERS (2019)

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Article Oncology

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Choh Yeung et al.

CANCER RESEARCH (2019)

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Article Multidisciplinary Sciences

Metabolic regulation of gene expression by histone lactylation

Di Zhang et al.

NATURE (2019)

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Article Oncology

BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells

Kaisheng Liu et al.

FRONTIERS IN ONCOLOGY (2019)

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Meeting Abstract Oncology

The lactate receptor Gpr81 on non-cancer cells promotes an immunosuppressive phenotype in the tumor microenvironment

Timothy Brown et al.

CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma

Sen Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Cell Biology

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Xianmin Mu et al.

CELL CYCLE (2018)

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Article Cell Biology

IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development

Isatou Bah et al.

CELLULAR IMMUNOLOGY (2018)

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Review Physiology

Lactate metabolism: historical context, prior misinterpretations, and current understanding

Brian S. Ferguson et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells

Ayumu Takeno et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Multidisciplinary Sciences

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Cyril Corbet et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

MiR-101 inhibits cell proliferation and invasion of pancreatic cancer through targeting STMN1

Lin Zhu et al.

CANCER BIOMARKERS (2018)

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Article Cell Biology

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Maria Apicella et al.

CELL METABOLISM (2018)

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Article Cell Biology

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer

Li Yan et al.

AGING-US (2018)

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Article Microbiology

Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development

Yong-Soo Lee et al.

CELL HOST & MICROBE (2018)

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Article Urology & Nephrology

Inhibition of LDHA Deliver Potential Anticancer Performance in Renal Cell Carcinoma

Xinsheng Wang et al.

UROLOGIA INTERNATIONALIS (2017)

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Article Oncology

Down-regulation of DAB2IP promotes colorectal cancer invasion and metastasis by translocating hnRNPK into nucleus to enhance the transcription of MMP2

X. H. Zhu et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Multidisciplinary Sciences

Glucose feeds the TCA cycle via circulating lactate

Sheng Hui et al.

NATURE (2017)

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Article Biochemistry & Molecular Biology

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

J. Feng et al.

ONCOGENE (2017)

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Article Biochemistry & Molecular Biology

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

L. Jin et al.

ONCOGENE (2017)

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Article Surgery

FX11 inhibits aerobic glycolysis and growth of neuroblastoma cells

Eric J. Rellinger et al.

SURGERY (2017)

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Review Cell Biology

Metabolic Interactions in the Tumor Microenvironment

Costas A. Lyssiotis et al.

TRENDS IN CELL BIOLOGY (2017)

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Article Multidisciplinary Sciences

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Tohru Takaki et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Stephen T. Hallett et al.

CELL REPORTS (2017)

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Article Oncology

MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy

Mounia Beloueche-Babari et al.

CANCER RESEARCH (2017)

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Article Genetics & Heredity

Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity

Waldemar Wagner et al.

DNA REPAIR (2017)

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Article Oncology

Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra

Juliann Chmielecki et al.

CANCER RESEARCH (2017)

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Article Cell Biology

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

Jhudit Perez-Escuredo et al.

CELL CYCLE (2016)

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Article Chemistry, Medicinal

Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy

Reshma Rani et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

Bethany Nancolas et al.

BIOCHEMICAL JOURNAL (2016)

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Article Biochemistry & Molecular Biology

Monocarboxylate transporters in the brain and in cancer

Jhudit Perez-Escuredo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Mechanism of antineoplastic activity of lonidamine

Kavindra Nath et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)

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Review Oncology

c-Rel and its many roles in cancer: an old story with new twists

Jill E. Hunter et al.

BRITISH JOURNAL OF CANCER (2016)

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Article Pharmacology & Pharmacy

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

R. S. Jones et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)

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Article Oncology

Metabolic alterations in bladder cancer: applications for cancer imaging

Terry Whyard et al.

EXPERIMENTAL CELL RESEARCH (2016)

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Article Endocrinology & Metabolism

Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy

Basetti Madhu et al.

METABOLOMICS (2016)

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Article Biochemistry & Molecular Biology

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau et al.

NATURE CHEMICAL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Lactate metabolism is associated with mammalian mitochondria

Ying-Jr Chen et al.

NATURE CHEMICAL BIOLOGY (2016)

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Article Neurosciences

Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

Juan Li et al.

NEUROREPORT (2016)

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Article Biology

Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling

Di Xie et al.

SCIENCE CHINA-LIFE SCIENCES (2016)

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Article Oncology

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells

Zhi-guang Fu et al.

ONCOTARGET (2016)

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Article Oncology

miR-223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1

Wei Lu et al.

ONCOTARGET (2016)

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Article Multidisciplinary Sciences

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

Agustina Errea et al.

PLOS ONE (2016)

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Article Oncology

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells

Ricardo Amorim et al.

CANCER LETTERS (2015)

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Article Oncology

Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt-mTOR signaling pathway

Zhi Zhao et al.

CANCER LETTERS (2015)

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Review Neurosciences

The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

Cecilie Morland et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2015)

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Review Cell Biology

Metabolic pathways promoting cancer cell survival and growth

Lindsey K. Boroughs et al.

NATURE CELL BIOLOGY (2015)

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Editorial Material Medicine, General & Internal

Is Cancer a Genetic Disease or a Metabolic Disease?

David S. Wishart

EBIOMEDICINE (2015)

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Article Biochemistry & Molecular Biology

CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance

Julieta Afonso et al.

MOLECULAR CARCINOGENESIS (2015)

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Article Oncology

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

M. Maftouh et al.

BRITISH JOURNAL OF CANCER (2014)

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Article Oncology

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway

Zhiqiang Zhao et al.

CANCER LETTERS (2014)

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Article Oncology

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

Christina L. Roland et al.

CANCER RESEARCH (2014)

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Article Neurosciences

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

Knut H. Lauritzen et al.

CEREBRAL CORTEX (2014)

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Article Medicine, Research & Experimental

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

Thomas Condamine et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Oncology

A Novel Fusion of TPR and ALK in Lung Adenocarcinoma

Yoon-La Choi et al.

JOURNAL OF THORACIC ONCOLOGY (2014)

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Review Cell Biology

Comprehensive review on lactate metabolism in human health

M. Adeva-Andany et al.

MITOCHONDRION (2014)

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Article Oncology

Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux

Nihed Draoui et al.

MOLECULAR CANCER THERAPEUTICS (2014)

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Article Multidisciplinary Sciences

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Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

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CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

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Targeting lactate-related cell cycle activities for cancer therapy

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