期刊
SEMINARS IN CANCER BIOLOGY
卷 86, 期 -, 页码 1231-1243出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2022.10.009
关键词
Lactate; Cancer; Warburg effect; Cell cycle; Lactylation
类别
资金
- Natural Science Foundation of Fujian Province
- Science and Technology Development Fund of Macau SAR (FDCT)
- [2020J01311402]
- [0055/2019/A1]
- [0010/2021/AFJ]
This review summarizes the functions and mechanisms of lactate in cancer, and analyzes protein lactylation in different rat organs. The unresolved challenges in this field are discussed, along with the potential application of lactate-related cell cycle activities in targeted cancer therapy.
Lactate has long been considered as a metabolic by-product of aerobic glycolysis for cancer. However, more and more studies have shown that lactate can regulate cancer progression via multiple mechanisms such as cell cycle regulation, immune suppression, energy metabolism and so on. A recent discovery of lactylation attracted a lot of attention and is already a hot topic in the cancer field. In this review, we summarized the latest functions of lactate and its underlying mechanisms in cancer. We also included our analysis of protein lactylation in different rat organs and compared them with other published lactylation data. The unresolved challenges in this field were discussed, and the potential application of these new discoveries of lactate-related cell cycle activities for cancer target therapy was speculated.
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