4.6 Article

Tracing the electron flow in redox metabolism: The appropriate distribution of electrons is essential to maintain redox balance in cancer cells

期刊

SEMINARS IN CANCER BIOLOGY
卷 87, 期 -, 页码 32-47

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2022.10.005

关键词

Redox balance; Cancer metabolism; NADPH; ROS; Antioxidant system

类别

资金

  1. Zhejiang Provincial Department of Sciences and Technologies [82073038]
  2. China Natural Sciences Foundation [2017XZZX001-01]
  3. Fundamental Research Funds for the Central Universities [2019FZJD009]
  4. [2018C03009]

向作者/读者索取更多资源

Cancer cells exhibit higher oxidation-reduction reactions compared to normal cells, necessitating proper electron distribution to maintain redox balance. Targeting the redox regulation network could present new therapeutic opportunities for cancer treatment.
Cancer cells are characterized by sustained proliferation, which requires a huge demand of fuels to support energy production and biosynthesis. Energy is produced by the oxidation of the fuels during catabolism, and biosynthesis is achieved by the reduction of smaller units or precursors. Therefore, the oxidation-reduction (redox) reactions in cancer cells are more active compared to those in the normal counterparts. The higher activity of redox metabolism also induces a more severe oxidative stress, raising the question of how cancer cells maintain the redox balance. In this review, we overview the redox metabolism of cancer cells in an electron -tracing view. The electrons are derived from the nutrients in the tumor microenvironment and released dur-ing catabolism. Most of the electrons are transferred to NAD(P) system and then directed to four destinations: energy production, ROS generation, reductive biosynthesis and antioxidant system. The appropriate distribution of these electrons achieved by the function of redox regulation network is essential to maintain redox homeo-stasis in cancer cells. Interfering with the electron distribution and disrupting redox balance by targeting the redox regulation network may provide therapeutic implications for cancer treatment.

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