4.8 Article

Dynamics of T cell repertoire renewal following autologous hematopoietic stem cell transplantation in multiple sclerosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Characterization of Antigen-Induced CD4+T-Cell Senescence in Multiple Sclerosis

Paula Tomas-Ojer et al.

Summary: Antigen-induced T-cell exhaustion and T-cell senescence control effector T-cell responses. This study analyzes the markers of CD4+ T-cell senescence in patients with multiple sclerosis (MS) and finds their correlation with markers of neurodegeneration, suggesting their relevance in disease pathogenesis and regulation.

FRONTIERS IN NEUROLOGY (2022)

Editorial Material Biochemistry & Molecular Biology

Guilty by association: Epstein-Barr virus in multiple sclerosis

Amit Bar-Or et al.

Summary: Two new studies provide strong evidence from epidemiology and mechanism, which may have implications for strategies targeting the Epstein-Barr virus.

NATURE MEDICINE (2022)

Article Multidisciplinary Sciences

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis

Mattias Bronge et al.

Summary: This study screened for autoantigens in multiple sclerosis (MS) using a novel method, and discovered four previously unreported autoantigens. The study also demonstrated the heterogeneity of autoreactive profiles and highlighted potential targets for future diagnostic tools and therapies for MS.

SCIENCE ADVANCES (2022)

Article Biochemistry & Molecular Biology

Dynamics of Inflammatory and Neurodegenerative Biomarkers after Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Josefine Ruder et al.

Summary: Autologous hematopoietic stem cell transplantation (aHSCT) is an effective treatment for multiple sclerosis (MS), which normalizes pathological processes and enhances beneficial processes. Biomarker analysis of MS patients undergoing aHSCT showed that serum levels of CXCL10, NfL, and GFAP significantly increased one month after transplantation, but returned to normal after one to two years. Levels of GFAP in cerebrospinal fluid (CSF) increased 24 months after aHSCT, indicating sustained astroglia activation. Other CSF markers remained relatively stable.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Clinical Neurology

Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis

Yin Xu et al.

Summary: The study investigates the association between hospital-diagnosed infections before age 20 and the risk of a subsequent multiple sclerosis diagnosis. Results indicate that infections during adolescence, particularly CNS infections, increase the risk of multiple sclerosis diagnosis. This increased risk cannot be solely explained by infectious mononucleosis, pneumonia, or CNS infections.
Review Immunology

Dynamics of thymus function and T cell receptor repertoire breadth in health and disease

David Granadier et al.

Summary: The diversity of the T cell receptor repertoire in the thymus is crucial for immune responses against pathogens and malignancies, but thymic function is sensitive to negative stimuli such as acute insult or chronic damage. These insults can lead to decreased immune responses, highlighting the importance of maintaining thymic function for overall immune health.

SEMINARS IN IMMUNOPATHOLOGY (2021)

Article Biology

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Mariona Baliu-Pique et al.

Summary: The study found that in patients after autologous hematopoietic stem cell transplantation (autoHSCT), the production rates of most T- and B-cell subsets increased significantly, but accompanied by an increase in cell loss rates, which persisted even after cell numbers normalized.
Article Immunology

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Josefine Ruder et al.

Summary: It was found that after autologous hematopoietic stem cell transplantation, the relative frequency and absolute numbers of CD56(bright) NK cells in patients with multiple sclerosis increased, while all studied innate-like T cell populations decreased.

FRONTIERS IN IMMUNOLOGY (2021)

Article Clinical Neurology

T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis

Carolina Cruciani et al.

Summary: This study delved into T-cell specificities in multiple sclerosis (MS), revealing differences in immune phenotypes and transcriptome analysis among patients with different intrathecal T-cell specificities, highlighting the importance of T-cell specificity in MS pathogenesis and suggesting potential for improved patient classification and development of antigen-specific tolerization strategies.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Article Immunology

Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey

Mohamed A. ElTanbouly et al.

Summary: The fate of T cells is controlled by a series of checkpoints, including quiescence, ignorance, anergy, exhaustion, senescence, and death, which regulate their immune quality and intensity. These checkpoints play important roles in maintaining T cell tolerance and preventing excessive inflammation.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Clinical Neurology

The multiple sclerosis gut microbiota: A systematic review

Ali Mirza et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Article Medicine, Research & Experimental

Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis

Kristina M. Harris et al.

JCI INSIGHT (2020)

Article Biochemical Research Methods

Genesis of the T-cell receptor

Thomas Dupic et al.

PLOS COMPUTATIONAL BIOLOGY (2019)

Article Clinical Neurology

Prospective phase II clinical trial of autologous haematopoietic stem cell transplant for treatment refractory multiple sclerosis

John J. Moore et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Multidisciplinary Sciences

Comprehensive Analysis of TCR-β Repertoire in Patients with Neurological Immune-mediated Disorders

Alessandra de Paula Alves Sousa et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

Mikhail Shugay et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Immunology

TCRαβ+CD3+CD4-CD8- (double negative) T cells in autoimmunity

D. Brandt et al.

AUTOIMMUNITY REVIEWS (2018)

Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Article Medicine, Research & Experimental

Multiple Sclerosis Pathology

Hans Lassmann

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Article Immunology

Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity

Kristina M. Harris et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

Ivan Jelcic et al.

Review Immunology

Regulatory T cells in multiple sclerosis and myasthenia gravis

K. M. Danikowski et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Review Clinical Neurology

Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis

Paolo A. Muraro et al.

NATURE REVIEWS NEUROLOGY (2017)

Review Immunology

CD69: from activation marker to metabolic gatekeeper

Danay Cibrian et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

Article Cell Biology

Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing

Xianliang Hou et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

Article Biochemical Research Methods

OMIP-033: A comprehensive single step staining protocol for human T- and B-cell subsets

Tess Brodie et al.

CYTOMETRY PART A (2016)

Article Multidisciplinary Sciences

Anoctamin 2 identified as an autoimmune target in multiple sclerosis

Burcu Ayoglu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Clinical Neurology

Immunology of Multiple Sclerosis

Mireia Sospedra et al.

SEMINARS IN NEUROLOGY (2016)

Article Clinical Neurology

Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update

Alberto Ascherio et al.

SEMINARS IN NEUROLOGY (2016)

Article Clinical Neurology

Intrathecal T-cell clonal expansions in patients with multiple sclerosis

Alessandra de Paula Alves Sousa et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

Review Immunology

The immunogenetics of multiple sclerosis: A comprehensive review

Jill A. Hollenbach et al.

JOURNAL OF AUTOIMMUNITY (2015)

Review Cell Biology

CD4(+)/CD8(+) double-positive T cells: more than just a developmental stage?

Nana H. Overgaard et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2015)

Article Multidisciplinary Sciences

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

Simone Becattini et al.

SCIENCE (2015)

Article Immunology

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia

Chittappen K. Prajeeth et al.

BRAIN BEHAVIOR AND IMMUNITY (2014)

Article Medicine, Research & Experimental

T cell repertoire following autologous stem cell transplantation for multiple sclerosis

Paolo A. Muraro et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Immunology

The who's who of T-cell differentiation: Human memory T-cell subsets

Yolanda D. Mahnke et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

Using synthetic templates to design an unbiased multiplex PCR assay

Christopher S. Carlson et al.

NATURE COMMUNICATIONS (2013)

Article Hematology

Blood graft composition after plerixafor injection in patients with NHL

Ville Varmavuo et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2012)

Article Clinical Neurology

No proinflammatory signature in CD34+ hematopoietic progenitor cells in multiple sclerosis patients

A. Lutterotti et al.

MULTIPLE SCLEROSIS JOURNAL (2012)

Review Pharmacology & Pharmacy

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Cris S. Constantinescu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Telomere length measurement by a novel monochrome multiplex quantitative PCR method

Richard M. Cawthon

NUCLEIC ACIDS RESEARCH (2009)

Article Biochemical Research Methods

Method for assessing the similarity between subsets of the T cell receptor repertoire

Vanessa Venturi et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2008)

Article Biochemistry & Molecular Biology

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Hania Kebir et al.

NATURE MEDICINE (2007)

Article Geriatrics & Gerontology

Telomere shortening and ageing

H. Jiang et al.

ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE (2007)

Article Biochemical Research Methods

Methods for comparing the diversity of samples of the T cell receptor repertoire

Vanessa Venturi et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2007)

Article Immunology

CD4+CD8+double positive (DP) T cells in health and disease

Y Parel et al.

AUTOIMMUNITY REVIEWS (2004)

Article Immunology

The CD4-Thl model for multiple sclerosis: a crucial re-appraisal

H Lassmann et al.

TRENDS IN IMMUNOLOGY (2004)

Article Biochemical Research Methods

Sensitive and viable identification of antigen-specific CD8+T cells by a flow cytometric assay for degranulation

MR Betts et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2003)

Article Immunology

Hematopoietic stem cell graft manipulation as a mechanism of immunotherapy

JE Talmadge

INTERNATIONAL IMMUNOPHARMACOLOGY (2003)

Review Immunology

T-cell development and the CD4-CD8 lineage decision

RN Germain

NATURE REVIEWS IMMUNOLOGY (2002)

Article Immunology

Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

AW Goldrath et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

Article Immunology

Cutting edge: Naive T cells masquerading as memory cells

K Murali-Krishna et al.

JOURNAL OF IMMUNOLOGY (2000)