期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 14, 期 661, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.abo1800
关键词
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资金
- Marie-Sklodowska Curie Actions of the European Commission [H2020-MSCA-IF-2017 793419]
- Swiss National Science Foundation [PZ00P3_180018]
- Parkinson Schweiz Foundation
- Funds Gustaaf Hamburger of the Fondation Philanthropia
- Defitech Foundation
- Baasch-Medicus Foundation
- Swiss National Science Foundation (SNF) [PZ00P3_180018] Funding Source: Swiss National Science Foundation (SNF)
The disruption of subthalamic nucleus dynamics in Parkinson's disease has been found to impair walking. Researchers have developed a neurorobotic platform to investigate how the subthalamic nucleus encodes the key components of walking. They discovered that the subthalamic nucleus encodes the initiation, termination, and amplitude of leg muscle activation during walking. These findings can potentially be used to improve walking in people with Parkinson's disease using neuroprosthetic systems.
Disruption of subthalamic nucleus dynamics in Parkinson's disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson's disease. We conceived a neurorobotic platform embedding an isokinetic dynamometric chair that allowed us to deconstruct key components of walking under well-controlled conditions. We exploited this platform in 18 patients with Parkinson's disease to demonstrate that the subthalamic nucleus encodes the initiation, termination, and amplitude of leg muscle activation. We found that the same fundamental principles determine the encoding of leg muscle synergies during standing and walking. We translated this understanding into a machine learning framework that decoded muscle activation, walking states, locomotor vigor, and freezing of gait. These results expose key principles through which subthalamic nucleus dynamics encode walking, opening the possibility to operate neuroprosthetic systems with these signals to improve walking in people with Parkinson's disease.
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