期刊
SCHIZOPHRENIA BULLETIN
卷 48, 期 -, 页码 S45-S55出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbac111
关键词
Bruno Schulz; schizophrenia; genetics; history; 1933
类别
In his 1933 article, Bruno Schulz reported a follow-up study on schizophrenic probands and their relatives, exploring the validity of using schizophrenia as a unit-character for genetic analysis. He proposed different subgroupings of probands and compared them based on risk for schizophrenia in siblings and resemblance among affected pairs. His findings raised important questions about the clinical and etiological heterogeneity of schizophrenia.
In his 1933 article, Bruno Schulz reported a follow-up and reanalysis of the schizophrenic probands and their relatives first studied by Rudin 20 years earlier that sought to clarify whether schizophrenia was a valid unit-character for Mendelian genetic analysis. He proposed a range of subgroupings of probands, particularly traditional subtyping, presence or absence of identifiable causal influences, and outcome. He then compared those subgroupings in several ways, most commonly by the risk for schizophrenia in their siblings and by the level of resemblance among proband-sibling affected pairs. Of his many findings, those of greatest interest included (1) probands with possible and probable physical causes, particularly those with head trauma, had substantially lower risk of illness in siblings, (2) probands with a hebephrenic subtype had a striking elevation of risk for schizophrenia in siblings, (3) probands with psychological causes had higher rates of good outcome, (4) proband-sibling pairs resembled one another for the classical schizophrenic subtypes, and (5) an absence of any cases of schizophrenia in siblings of a small group of schizophrenic probands with birth complications, convulsions, and skull deformities. Schulz used this sample in a fundamentally different way than Rudin. Rather than seeking for Mendelian transmission patterns, Schulz used family data to evaluate hypothesis about clinical/etiological heterogeneity, thereby presaging many subsequent family studies of psychiatric disorders. While Schulz did not claim to have proved the etiologic heterogeneity of schizophrenia, he raised important questions, still unanswered, about whether schizophrenia is a legitimate unit-character appropriate for genetic analysis.
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