The role of circular RNA hsa_circ_0001789 as a diagnostic biomarker in gastric carcinoma

Background Circular RNA (circRNA) is a kind of endogenous non-coding RNAs and has shown diagnostic values in various cancers. This study aimed to explore whether hsa_circ_0001789 could be a novel biomarker for gastric cancer (GC). Methods Quantitative reverse transcriptase PCR was used to detect the expression of hsa_circ_0001789 in 108 paired GC and paracancerous tissues as well as in 24 paired plasma specimens. Possible associations between hsa_circ_0001789 expression and clinicopathologic factors of GC patients were examined using one-way ANOVA. A receiver operating characteristic (ROC) curve was established to investigate the diagnostic value of hsa_circ_0001789 in GC. Results GC tissues and plasma samples showed down-regulated hsa_circ_0001789 levels than their counterparts, which were closely correlated with the malignant characteristics of GC. The area under the ROC curve (AUC) of hsa_circ_0001789 in GC tissues was 0.82, while the cut-off value was 9.5, indicating a favorable diagnostic value. Compared with the traditional tumor biomarkers, hsa_circ_0001789 had preferred AUCs that reached 0.786 for predicting the stage of invasion, 0.603 for predicting the stage of lymphatic metastasis, 0.722 for predicting the stage of distant metastasis, and 0.786 for predicting TNM stage. Conclusions Hsa_circ_0001789 may be a novel biomarker for the diagnosis of gastric carcinoma.

Automated summary

A study found that hsa_circ_0001789 may serve as a novel biomarker for gastric cancer (GC). The expression levels of hsa_circ_0001789 were down-regulated in GC tissues and plasma samples, and were closely correlated with the malignant characteristics of GC. Compared to traditional tumor biomarkers, hsa_circ_0001789 showed better accuracy in predicting the stage of invasion, lymphatic metastasis, distant metastasis, and TNM stage of GC.