γ-Cyclodextrin Based Metal-Organic Framework As a Niflumic Acid Delivery System

A metal-organic framework based on gamma-cyclodextrin and K+ cations synthesized by antisolvent vapor diffusion method is proposed as a delivery system for niflumic acid, a non-steroidal anti-inflammatory agent with limited aqueous solubility. Methods of loading niflumic acid into the framework are discussed. The resulting composites are characterized via XRD, low-temperature nitrogen sorption/desorption, and IR spectroscopy. Encapsulation in a metal-organic framework has effect on the kinetics of niflumic acid release and its membrane permeability.

Automated summary

A metal-organic framework based on gamma-cyclodextrin and K+ cations is proposed as a delivery system for niflumic acid, and its effects on the release kinetics and membrane permeability of niflumic acid are investigated.