期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 48, 期 6, 页码 1291-1298出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162022060292
关键词
Crataegus scabrifolia; rosaceae; chemical constituents; triterpenoids; lipid-lowering activity; molecular docking
资金
- Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities' Association [2019FH001-050]
- Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan [202105AG070003]
- Yunnan Fundamental Research Projects [202201AT070005]
- Scientific Research Initiation Fund of Dali University for Doctor [KYBS201734]
This study investigated the chemical constituents of wild Crataegus scabrifolia fruits and their lipid-lowering activities. Ten triterpenoids were isolated and identified, with some of them exhibiting significant lipid-lowering activities. The results suggest that these triterpenoids may have potential as lipid-lowering agents.
To investigate the chemical constituents of fruits of wild species of Crataegus scabrifolia and their lipid-lowering activities. The compounds were isolated and purified by various column chromatography, and their structures were identified based on the comprehensive analyses of the physicochemical properties and spectroscopic data. The lipid-lowering activities of isolated compounds were evaluated by a cellular model of HepG2 in vitro. Ten triterpenoids were obtained from the 95% ethanol extract of the fruits of wild species of C. scabrifolia and identified as alpha-amyrin (I), ursolic acid (II), pomolic acid (III), tormentic acid (IV), euscaphic acid (V), 2 alpha,19 alpha-dihydroxy-3-oxo-urs-12-en-28-oic acid (VI), fupenzic acid (VII), oleanolic acid (VIII), beta-amyrin (IX), and 3-epifriedelinol (X). Compounds (I), (IX), and (X) were isolated from the genus Crataegus for the first time, and compounds (III-VIII) were isolated from the C. scabrifolia for the first time. Compounds (V-VII) showed significant lipid-lowering activities in vitro with lipid-lowering rates of 8.9 +/- 4.3%, 12.0 +/- 4.6%, and 6.5 +/- 5.5% at a concentration of 200 mu mol/L. Molecular docking results suggested that the ACC may be a target of lipid-lowering activity for Crataegus triterpenoids.
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