期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 48, 期 5, 页码 1101-1104出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162022050077
关键词
imidazolones; chromophores; fluorescence
资金
- Russian Science Foundation [18-73-10105]
A novel derivative of the conformationally locked derivative of the green fluorescent protein chromophore is reported. The presence of an additional aryl substituent leads to a decrease in fluorescence intensity without causing absorption and emission spectra shifts. Future research can explore the use of electron-withdrawing groups for more efficient conjugation.
We report a novel derivative of the conformationally locked derivative of the green fluorescent protein chromophore, (Z)-5-((2-(difluoroboryl)-4-(dimethylamino)phenyl)(4-(dimethylamino)phenyl)methylene)-2-propyl-3,5-dihydro-4H-imidazol-4-on. The presence of an additional aryl substituent in the structure causes a decrease in the fluorescence intensity and does not lead to absorption and emission spectra shifts. A promising direction of research is the replacement of this substituent with the electron-withdrawing groups, such as the nitrile or CF3 group, capable of more efficient conjugation with the pi-system of the molecule.
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