期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 45, 期 4, 页码 1024-1033出版社
WILEY
DOI: 10.1002/jmri.25432
关键词
myocardial stiffness; cardiac magnetic resonance elastography; cardiac MRE; myocardial infarction
资金
- American Heart Association [13SDG14690027]
- Center for Clinical and Translational Sciences [UL1TR000090]
- NIH/NHLBI [NIH-R01HL124096]
PurposeTo estimate change in left ventricular (LV) end-systolic and end-diastolic myocardial stiffness (MS) in pigs induced with myocardial infarction (MI) with disease progression using cardiac magnetic resonance elastography (MRE) and to compare it against ex vivo mechanical testing, LV circumferential strain, and magnetic resonance imaging (MRI) relaxometry parameters (T-1, T-2, and extracellular volume fraction [ECV]). Materials and MethodsMRI (1.5T) was performed on seven pigs, before surgery (Bx), and 10 (D10), and 21 (D21) days after creating MI. Cardiac MRE-derived MS was measured in infarcted region (MIR) and remote region (RR), and validated against mechanical testing-derived MS obtained postsacrifice on D21. Circumferential strain and MRI relaxometry parameters (T-2, T-1, and ECV) were also obtained. Multiparametric analysis was performed to determine correlation between cardiac MRE-derived MS and 1) strain, 2) relaxometry parameters, and 3) mechanical testing. ResultsMean diastolic (D10: 5.090.6 kPa; D21: 5.450.7 kPa) and systolic (D10: 5.720.8 kPa; D21: 6.34 +/- 1.0 kPa) MS in MIR were significantly higher (P < 0.01) compared to mean diastolic (D10: 3.97 +/- 0.4 kPa; D21: 4.12 +/- 0.2 kPa) and systolic (D10: 5.08 +/- 0.6 kPa; and D21: 5.16 +/- 0.6 kPa) MS in RR. The increase in cardiac MRE-derived MS at D21 (MIR) was consistent and correlated strongly with mechanical testing-derived MS (r(diastolic)=0.86; r(systolic)=0.89). Diastolic MS in MIR demonstrated a negative correlation with strain (r=0.58). Additionally, cardiac MRE-derived MS demonstrated good correlations with post-contrast T-1 (r(diastolic)=-0.549; r(systolic)=-0.741) and ECV (r(diastolic)=0.548; r(systolic)=0.703), and no correlation with T-2. ConclusionAs MI progressed, cardiac MRE-derived MS increased in MIR compared to RR, which significantly correlated with mechanical testing-derived MS, T-1 and ECV.
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