Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases

In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.

Automated summary

This review highlights the importance of mitochondrial dynamics in neurodegenerative diseases, particularly abnormal mitochondrial divisions under pathological conditions. It provides a detailed description of the relationship between mitochondrial dynamics and neurodegenerative diseases, and summarizes the detection indicators in basic experiments, aiming to provide references for further mechanism exploration and therapeutic targets.