Green and one-pot synthesis of novel amidoalkyl naphthols using triethanolammonium acetate [(OHCH2CH2)3NH][OAc]) ionic liquid and their anti-H.pylori activity

Nearly half of the world's population have been infected with Helicobacter pylori (H. pylori) which is known as the main cause of chronic gastritis, duodenal ulcer illness as well as stomach carcinoma. In this work, an efficient, one-pot synthesis of amidoalkyl naphthol derivatives and their in vitro anti-Helicobacter pylori activity are reported. The reaction proceeds via multi-component condensation of 2-naphthol, (hetero) aromatic aldehydes and urea/thiourea/acetamide/2-aminothiazole/4-nitrothiazol-2-amine/2-aminopyridine under solvent-free condition. This protocol includes some salient features, such as using triethanolammonium acetate ([OHCH2CH2)(3)NH][OAc]) ionic liquid as a green, clean and reusable catalyst, high yields, no column chromatography, and low cost. By comparing the inhibition zone of the target compounds, 6e and 6j could be considered as the best anti-helicobacter agent.

Automated summary

This work presents an efficient method for the synthesis of amidoalkyl naphthol derivatives and their in vitro anti-Helicobacter pylori activity. The method uses a green and reusable catalyst, shows high yields, requires no column chromatography, and is cost-effective.