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Mitochondrial Dysfunction in Polycystic Ovary Syndrome

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Article Endocrinology & Metabolism

Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome

Alba Moreno-Asso et al.

Summary: The study investigated the gene expression profile of skeletal muscle in women with PCOS and found that there was altered expression of genes associated with mitochondrial function. However, this altered gene expression was not preserved in cultured myotubes, suggesting that extracellular factors rather than genetic or epigenetic factors may be responsible for this alteration. Altered expression of mitochondrial-associated genes in skeletal muscle may contribute to the impaired energy metabolism in PCOS.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2022)

Review Endocrinology & Metabolism

Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

Anju E. Joham et al.

Summary: PCOS is a common endocrinopathy that affects reproductive-aged women, with a complex etiology and heterogeneous clinical features that can manifest as early as adolescence and develop into multiple system manifestations in adulthood. Challenges lie in diagnosing and understanding the natural history of PCOS.

CLINICAL ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Androgen Excess Induced Mitochondrial Abnormality in Ovarian Granulosa Cells in a Rat Model of Polycystic Ovary Syndrome

Linyi Song et al.

Summary: Excess androgen could damage the mitochondrial ultrastructure and function of ovarian granulosa cells in PCOS model rats by down-regulating the expression of NDUFB8 and ATP5j.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Obstetrics & Gynecology

Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population-based cohort study

Linda Kujanpaa et al.

Summary: This population-based follow-up study found that women with polycystic ovary syndrome (PCOS) had increased risk of comorbidities, medication use, and healthcare service use, independent of body mass index. The study also identified specific diseases that were more prevalent in women with PCOS, such as migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2022)

Article Biochemistry & Molecular Biology

HB-EGF induces mitochondria) dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca2+-FOXO1 pathway

Ji-Cheng Huang et al.

Summary: This study found that HB-EGF is abundant in PCOS patients and may induce excessive estrogen secretion, mitochondrial dysfunction, and granulosa cell apoptosis. The results reveal the important role of HB-EGF in the pathogenesis of PCOS.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Article Biochemistry & Molecular Biology

Androgen Reduces Mitochondrial Respiration in Mouse Brown Adipocytes: A Model for Disordered Energy Balance in Polycystic Ovary Syndrome

Avi Lerner et al.

Summary: Polycystic ovary syndrome (PCOS) is associated with reduced postprandial thermogenesis and abnormalities in adipose tissue function, with excess androgen inhibiting brown adipogenesis, attenuating thermogenic activation, and reducing mitochondrial respiration in brown adipose tissue (BAT). These findings may contribute to the reduced postprandial thermogenesis and increased tendency to obesity observed in women with PCOS.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Polymorphisms and haplotype of mitochondrial DNA D-loop region are associated with polycystic ovary syndrome in a Chinese population

Xiaohong Deng et al.

Summary: Certain mtDNA D-loop variants were found to be associated with decreased risk of PCOS in a Chinese population, but no significant correlation was found between D-loop polymorphisms and clinical characteristics within the PCOS group. Haplotype analysis suggested that a specific haplotype was significantly associated with decreased risk of PCOS.

MITOCHONDRION (2021)

Article Cell Biology

Cell-free mtDNA level and its biomarker potency for ART outcome are different in follicular fluid of PCOS and non-PCOS women

Maryam Qasemi et al.

Summary: PCOS patients have a lower level of FF cf-mtDNA compared to non-PCOS women, along with a reduction in the expression of mtDNA biogenesis genes in MGCs of the patients. While a significant association between FF cf-mtDNA level and ART outcome was observed in the control group, no correlation could be proved in the PCOS group. Moreover, the expression level of TFAM was negatively associated, while amounts of IL-6 and TNF alpha were positively correlated with FF cf-mtDNA level in both groups.

MITOCHONDRION (2021)

Article Endocrinology & Metabolism

Mitochondrial DNA 4977 bp Deletion in Peripheral Blood Is Associated With Polycystic Ovary Syndrome

Mujin Ye et al.

Summary: The study found a strong association between mtDNA(4977) DR and PCOS, suggesting that it may represent an independent risk factor for PCOS. Further research is needed to explore the potential value of mtDNA as a biomarker for PCOS.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Obstetrics & Gynecology

Midlife women's health consequences associated with polycystic ovary syndrome

A. T. Ali et al.

CLIMACTERIC (2020)

Article Endocrinology & Metabolism

Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS

Shanling Yi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Article Endocrinology & Metabolism

Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes

Neil R. Chappell et al.

ENDOCRINE CONNECTIONS (2020)

Article Endocrinology & Metabolism

Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study

Po-Kai Yang et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis

Veronica Yumiceba et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Clinical Neurology

Photosensitive Epilepsy and Polycystic Ovary Syndrome as Manifestations of MERRF

Josef Finsterer

CASE REPORTS IN NEUROLOGICAL MEDICINE (2020)

Article Medicine, Research & Experimental

Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR

Yu Ding et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Article Medicine, General & Internal

Polycystic ovary syndrome

Ricardo Azziz et al.

NATURE REVIEWS DISEASE PRIMERS (2016)