期刊
REGENERATIVE MEDICINE
卷 17, 期 11, 页码 805-817出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2022-0095
关键词
endometrium; exosome; extracellular vesicle; menstrual blood-derived stem cells; platelet-derived exosomes
资金
- Mayo Clinic Center for Regenerative Medicine
The study found that a platelet-derived purified exosome product (PEP) can be absorbed by various types of endometrial cells. PEP treatment can increase cell proliferation and wound healing capacity.
Aim: To investigate the regenerative effects of a platelet-derived purified exosome product (PEP) on human endometrial cells. Materials & methods: Endometrial adenocarcinoma cells (HEC-1A), endometrial stromal cells (T HESC) and menstrual blood-derived stem cells (MenSC) were assessed for exosome absorption and subsequent changes in cell proliferation and wound healing properties over 48 h. Results: Cell proliferation increased in PEP treated T HESC (p < 0.0001) and MenSC (p < 0.001) after 6 h and in HEC-1A (p < 0.01) after 12 h. PEP improved wound healing after 6 h in HEC-1A (p < 0.01) and MenSC (p < 0.0001) and in T HESC between 24 and 36 h (p < 0.05). Conclusion: PEP was absorbed by three different endometrial cell types. PEP treatment increased cell proliferation and wound healing capacity.
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