4.7 Article

Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biology

Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

Houda Kacem et al.

Summary: Research on delivering radiation at ultra-high dose rates (UHDRs) has gained interest in the radiation sciences, particularly due to the promising FLASH effect observed. The potential clinical implications of FLASH radiotherapy (FLASH-RT) are significant, as it could enhance treatment efficacy while minimizing toxicity. Pioneering research teams are now investigating the mechanisms and clinical translation of the FLASH effect in order to advance this new field of study.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Oncology

Ultrafast Tracking of Oxygen Dynamics During Proton FLASH

Mirna El Khatib et al.

Summary: This study presents a new method for tracking oxygen dynamics during radiation therapy and reveals the correlation between the FLASH effect and oxygen concentration. The results demonstrate that FLASH radiation therapy can better protect normal tissues, and the depletion of oxygen is correlated with oxygen concentration. This finding is significant for further investigation into the mechanism of the FLASH effect.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Model studies of the role of oxygen in the FLASH effect

Vincent Favaudon et al.

Summary: Standard radiotherapy facilities deliver doses at a rate of 0.1-0.4 Gy/s, while FLASH radiotherapy requires ultrahigh dose rates in microseconds. The FLASH effect is hypothesized to be dependent on oxygen tension, prompting various theoretical models.

MEDICAL PHYSICS (2022)

Article Biology

Oxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at Conventional and FLASH Dose Rates

Alexander L. Van Slyke et al.

Summary: FLASH is a form of high-dose-rate radiation therapy that can spare normal tissues while being effective in tumor control. The mechanism of normal tissue sparing effect in FLASH therapy may involve radiochemical oxygen depletion during dose delivery. This study used phosphorescence quenching method to measure oxygen partial pressure before, during, and after proton radiation delivery in solutions and in mice models. The results showed that the oxygen depletion was lower in FLASH dose rates compared to conventional dose rates. The recovery time was longer in tumor tissue, possibly due to the lower initial endogenous oxygen levels.

RADIATION RESEARCH (2022)

Article Oncology

Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo

Leonhard Karsch et al.

Summary: This study investigated the influence of beam pulse structure on the Flash effect in zebrafish embryos. It was found that the mean dose rate or treatment time played a decisive role in the normal tissue protecting Flash effect.

RADIOTHERAPY AND ONCOLOGY (2022)

Article Biology

Proton Irradiations at Ultra-High Dose Rate vs. Conventional Dose Rate: Strong Impact on Hydrogen Peroxide Yield

Guillaume Blain et al.

Summary: During ultra-high dose rate external radiation therapy, the production of hydrogen peroxide (H2O2) can be controlled by early heterogenous radiolysis processes, thus sparing healthy tissues while maintaining tumor control. This study provides experimental evidence for this phenomenon during UHDR proton-beam irradiations.

RADIATION RESEARCH (2022)

Article Oncology

Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams

Houda Kacem et al.

Summary: The study investigated the physico-chemical and biological responses to conventional and UHDR electron and proton beams, including conventional photons. The temporal structure and nature of the beams had an impact on both, with electron beams at >= 1400 Gy/s and proton beams at 0.1 and 1260 Gy/s found to have an isoefficient effect on sparing zebrafish embryos.

RADIOTHERAPY AND ONCOLOGY (2022)

Article Engineering, Biomedical

Modeling the effect of oxygen on the chemical stage of water radiolysis using GPU-based microscopic Monte Carlo simulations, with an application in FLASH radiotherapy

Youfang Lai et al.

Summary: Oxygen plays a critical role in determining initial DNA damages caused by ionizing radiation. Through modeling the chemical stage of water radiolysis with an explicit consideration of the oxygen effect using gMicroMC, it was found that oxygen significantly reduces the yields of chemical radicals, leading to the formation of highly toxic species. This study demonstrated the practical value of gMicroMC in large scale simulation problems, showing an efficient computational speedup when considering oxygen molecules in the simulation.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

Article Oncology

Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo

Xu Cao et al.

Summary: The study found that FLASH irradiation induces less oxygen consumption in vitro compared to conventional irradiation, potentially contributing to the sparing effect on normal tissues. In vivo experiments showed significant decrease in oxygen content in normal and tumor tissues after a single fraction of FLASH irradiation, confirming the sparing effect.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions

Jeannette Jansen et al.

Summary: Experimental investigation into the depletion of oxygen within water during FLASH irradiation with different radiation types (photons, protons, carbon ions) showed that oxygen consumption depends on dose, dose rate, and linear energy transfer (LET). Higher dose rates resulted in lower oxygen consumption, with no total depletion of oxygen observed for clinical doses.

MEDICAL PHYSICS (2021)

Article Oncology

Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage

Joerg Pawelke et al.

Summary: The study demonstrated that the zebrafish embryo model is suitable for investigating the radiobiological response of high dose rate irradiation. It also highlighted the importance of pulse dose rate and partial oxygen pressure (pO(2)) as relevant parameters during radiation.

RADIOTHERAPY AND ONCOLOGY (2021)

Article Oncology

Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients

Elise Konradsson et al.

Summary: The study of FLASH radiotherapy in canine cancer patients showed promising feasibility and efficacy, with proper dose control and safety monitoring in place. Adverse events were mild and manageable, paving the way for further research in veterinary and human clinical trials.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Anastasia Velalopoulou et al.

Summary: The study shows that F-PRT has fewer toxicities and can spare normal tissues while providing antitumor efficacy equivalent to standard proton therapy. F-PRT reduced skin injury, stem cell depletion, inflammation, and late effects in murine experiments, and was effective in controlling sarcoma models.

CANCER RESEARCH (2021)

Article Oncology

May oxygen depletion explain the FLASH effect? A chemical track structure analysis

Daria Boscolo et al.

Summary: The study investigated the oxygen depletion hypothesis in FLASH irradiation by simulating the chemical track evolution of 1 MeV electrons in oxygenated water. Results showed that oxygen depletion has a negligible impact on radiosensitivity under typical experimental oxygen conditions, contradicting the assumption that it is the major driving force behind the FLASH effect. The study suggests that while oxygenation plays a role in mediating the FLASH effect, oxygen depletion and radiation-induced transient hypoxia may not be the main mechanisms.

RADIOTHERAPY AND ONCOLOGY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

The FLASH effect depends on oxygen concentration

Gabriel Adrian et al.

BRITISH JOURNAL OF RADIOLOGY (2020)

Article Biochemistry & Molecular Biology

Impact of Target Oxygenation on the Chemical Track Evolution of Ion and Electron Radiation

Daria Boscolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Joseph D. Wilson et al.

FRONTIERS IN ONCOLOGY (2020)

Article Oncology

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients

Marie-Catherine Vozenin et al.

CLINICAL CANCER RESEARCH (2019)

Article Oncology

Clinical translation of FLASH radiotherapy: Why and how?

Jean Bourhis et al.

RADIOTHERAPY AND ONCOLOGY (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Dose rate dependence for different dosimeters and detectors: TLD, OSL, EBT films, and diamond detectors

L. Karsch et al.

MEDICAL PHYSICS (2012)

Article Instruments & Instrumentation

The Rossendorf radiation source ELBE and its FEL projects

F Gabriel et al.

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS (2000)