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Article
Immunology
Jose-Manuel Ramos-Rincon et al.
Summary: The hospitalization rate for HIV-infected individuals receiving antiretroviral therapy has significantly decreased since 2008. In the later years, non-AIDS conditions, including liver disease, cardiovascular events, non-AIDS cancers, and kidney insufficiency, have become more common reasons for hospital admissions. The rate of in-hospital deaths among HIV-infected individuals has also declined, with AIDS-related conditions being the leading cause of death, followed by liver disease, cardiovascular events, non-AIDS cancers, and kidney insufficiency.
Review
Immunology
Julia Del Amo et al.
Summary: The susceptibility and severity of SARS-CoV-2 infection in people with HIV is debated. Studies show contradictory findings, but most are conducted in high-income settings where the majority of HIV-positive individuals are on antiretroviral therapy. While some studies suggest increased severity of COVID-19 in people with HIV, it may be influenced by age and comorbidities.
Article
Immunology
Adrian M. Shields et al.
Summary: This study investigates the outcomes of 310 patients with primary or secondary immunodeficiency in the United Kingdom following SARS-CoV-2 infection, and finds significantly elevated mortality rates in both cohorts compared to the general population. Increasing age, pre-existing lymphopenia, and other co-morbidities are identified as additional risk factors for death from COVID-19 in this cohort.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Julieta Politi et al.
Summary: The study evaluated the impact of free HCV infection treatment with direct-acting antivirals in Spain, finding a favorable change in HCV-related mortality after the intervention, with an acceleration in the downward trends of mortality rates for HCV, HCC, and HIV disease. This suggests that scaling up free treatment with direct-acting antivirals has contributed to the observed improvements in HCV-related mortality, bringing HCV eradication closer to reality.
Article
Infectious Diseases
Chiara Fanciulli et al.
Summary: We assessed the prevalence of active HCV infection among people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. The prevalence of active HCV infection in PLWH was 2.2% in 2019, which was 90% lower than in 2015.
Review
Infectious Diseases
Celestin Danwang et al.
Summary: This systematic review and meta-analysis aimed to summarize the available information on the risk of hospitalization, severe disease, and death attributable to HIV in patients with COVID-19. The findings suggest that patients with HIV have an increased risk of hospital admission for COVID-19, and HIV seems to be independently associated with an increased risk of mortality in COVID-19 patients.
AIDS RESEARCH AND THERAPY
(2022)
Article
Infectious Diseases
Victor Moreno-Torres et al.
Summary: The study aimed to analyze the mortality and characteristics of deceased patients with COVID-19 during the first year of the pandemic. The findings showed no significant differences in age, sex, length of admission, or mortality between the three waves. The overall mortality rate was 12.9%. Advanced age and multiple pathologies were identified as common characteristics of non-survivors.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
Pontus Hedberg et al.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Haidong Wang et al.
Summary: This study estimated excess mortality from the COVID-19 pandemic in 191 countries and territories, as well as 252 subnational units in selected countries from Jan 1, 2020, to Dec 31, 2021. The findings showed that globally, there were 18.2 million excess deaths due to the COVID-19 pandemic during this period. The highest excess mortality rates were observed in countries such as India, the USA, Russia, Mexico, Brazil, Indonesia, and Pakistan.
Article
Immunology
Jordi Navarro
Summary: Liver-related diseases are a major cause of morbidity and mortality in people living with HIV. Factors such as alcoholism, viral infections, aging, and HIV-related processes contribute to the higher risk for liver pathologies and complications in this population. Antiretroviral therapy may have a positive impact on liver fibrosis in HIV patients with chronic liver disease.
Article
Gastroenterology & Hepatology
Thomas Marjot et al.
Summary: This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among patients with more advanced cirrhosis and those with alcohol-related liver disease.
JOURNAL OF HEPATOLOGY
(2021)
Review
Virology
Paola Costenaro et al.
Summary: This study reviewed the impact of SARS-CoV-2 on people living with HIV/AIDS (PLWHA), finding that the majority of patients were male with one or more comorbidities. Some patients required intensive care treatment and faced a risk of death, particularly males affected by ARV-related complications.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Review
Gastroenterology & Hepatology
Antonio Saviano et al.
Summary: COVID-19 infection caused by SARS-CoV-2 poses a diverse range of liver damage, from asymptomatic abnormalities to hepatic decompensation, which are correlated with disease severity and mortality rates. Although SARS-CoV-2 RNA has been detected in the liver of patients, the specific mechanism of infection and replication in liver cells remains unclear.
Review
Pediatrics
Giorgia Bucciol et al.
Summary: This review summarizes the course and outcome of COVID-19 in patients with IEIs, finding that most IEIs do not independently increase the risk of severe disease. In fact, some IEIs may even be protective against severe disease.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Immunology
Krishnan Bhaskaran et al.
Summary: This study found that people living with HIV in the UK are at a higher risk of COVID-19 mortality compared to those without HIV. Even after adjusting for age, sex, ethnicity, and a range of comorbidities, the elevated risk remained significant, especially among individuals of Black ethnicity. Targeted policies should be considered to address this increased risk in the evolving pandemic response.
Article
Immunology
Daniel O. Griffin et al.
Article
Medicine, General & Internal
James M. Tesoriero et al.
Summary: This cohort study conducted in New York State found that persons living with diagnosed HIV had poorer outcomes related to COVID-19 compared to persons living without diagnosed HIV. Previous HIV diagnosis was associated with higher rates of severe disease requiring hospitalization, and hospitalization risk increased with progression of HIV disease stage.
Article
Immunology
Daniel K. Nomah et al.
Summary: This study assessed factors associated with SARS-CoV-2 diagnosis and severe outcomes among people living with HIV. The findings showed that age, immigrant status, sexual orientation, chronic comorbidities, and other factors were associated with SARS-CoV-2 diagnosis and severe outcomes. Participants with detectable HIV viraemia, chronic comorbidities, and certain subpopulations were at increased risk of severe outcomes from COVID-19, highlighting the importance of prioritizing these groups in clinical management and vaccination programs.
Article
Immunology
Xueying Yang et al.
Summary: The study using N3C data in the US found that individuals with HIV infection have higher odds of COVID-19 death and hospitalisation, but lower odds of mild or moderate COVID-19. Factors such as older age, male gender, and specific racial/ethnic groups may exacerbate the risk of adverse COVID-19 outcomes among people with HIV.
Article
Medicine, General & Internal
Victor Moreno-Torres et al.
Summary: Over the past two decades, there has been an increase in admissions for SLE patients, however, the percentage of SLE as a cause of admission has decreased. On the contrary, cardiovascular disease, infections, and neoplasm have become the main reasons for admissions and mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Robert W. Eisinger et al.
Summary: The COVID-19 pandemic has significantly impacted persons living with HIV, requiring a coordinated global effort to accelerate research progress and implement evidence-based interventions to address the juxtaposition of these two pandemics.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Paddy Ssentongo et al.
Summary: Susceptibility to SARS-CoV-2 infection and mortality risk are higher among people living with HIV/AIDS compared to HIV-negative individuals. The beneficial effects of antiretroviral therapy in reducing infection and mortality risks for COVID-19 in PLWHA remain inconclusive. Prioritizing SARS-CoV-2 vaccination for persons with HIV is recommended to mitigate the increased risk associated with HIV infection.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Lopez-de-Andres et al.
Summary: The study found that patients with T2DM have a higher risk of hemorrhagic stroke and are less likely to undergo decompressive craniectomy during hospitalization, while women have a higher in-hospital mortality rate. There are sex differences in T2DM patients who have experienced hemorrhagic stroke, with higher incidence rates and more frequent decompressive craniectomy in men compared to women.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Infectious Diseases
Vicente Soriano et al.
Summary: After Christmas 2020, Madrid experienced a third wave of COVID-19 with distinct features including household transmission, prompt diagnosis with rapid antigen tests, lower severity and mortality rates, increased presence of the more transmissible B.1.1.7 strain, vaccination benefits, and higher rates of reinfections. By Easter 2021, a quarter of the population in Madrid had been infected, highlighting the need for massive and accelerated vaccination campaigns to prevent further waves.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Kevin M. De Cock et al.
Summary: The 40th anniversary of AIDS marks a milestone in the ongoing battle against the disease, with lessons learned from past epidemics like Ebola and the ongoing COVID-19 pandemic. While progress has been made, challenges remain in ending the AIDS epidemic, especially in the context of emerging health threats and the need for enhanced preparedness.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
QuanQiu Wang et al.
Summary: Patients with chronic liver disease, especially those with chronic non-alcoholic liver disease and non-alcoholic cirrhosis, are at significantly increased risk for COVID-19. African Americans with chronic liver disease are twice as likely to develop COVID-19 compared to Caucasians. COVID-19 patients with chronic liver disease have a higher death rate and hospitalization rate than those without liver disease.
Article
Gastroenterology & Hepatology
Yijia Li et al.
Summary: The study found that FIB-4 score is associated with mortality in COVID-19 hospitalized patients, with each unit increase in FIB-4 score linked to higher risk of death. FIB-4 score peaked and then normalized in the survivor group but failed to do so in the deceased group. Furthermore, FIB-4 was positively correlated with SARS-CoV-2 viral load and monocyte-associated cytokines, particularly interleukin-6 and interferon gamma-induced protein 10.
HEPATOLOGY COMMUNICATIONS
(2021)
Review
Public, Environmental & Occupational Health
Hossein Mirzaei et al.
Summary: This systematic review highlights the characteristics and conditions of patients with COVID-19-HIV co-infection, revealing a predominantly male population with an average age of 52.7 years, and a high percentage receiving antiretroviral treatment. Comorbidities include hypertension, obesity, chronic obstructive pulmonary disease, and diabetes, with fever and cough being the most common symptoms. Indicating the importance of identifying co-infections, addressing comorbidities, and maintaining a secure supply of antiretroviral treatment for people living with HIV during the COVID-19 pandemic.
Article
Immunology
Jose-Manuel Ramos et al.
Article
Medicine, General & Internal
Chaolin Huang et al.
Article
Medicine, General & Internal
Chaomin Wu et al.
JAMA INTERNAL MEDICINE
(2020)
Article
Medicine, General & Internal
Fei Zhou et al.
Article
Infectious Diseases
TJ Cooper et al.
Article
Multidisciplinary Sciences
Jerome Hadjadj et al.
Correction
Biochemistry & Molecular Biology
David M. Morens et al.
Review
Gastroenterology & Hepatology
Matthew B. Kaspar et al.
BMJ OPEN GASTROENTEROLOGY
(2017)
Article
Infectious Diseases
Pablo Labarga et al.
Article
Gastroenterology & Hepatology
S. Serrano-Villar et al.
JOURNAL OF VIRAL HEPATITIS
(2015)
Article
Infectious Diseases
Vincent Soriano et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2010)
Article
Immunology
Vincent Soriano et al.
JOURNAL OF INFECTIOUS DISEASES
(2008)
