4.7 Article

Altered frontoparietal connectivity in patients with obsessive-compulsive disorder during an fMRI cognitive reappraisal task

期刊

PSYCHIATRY RESEARCH
卷 317, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2022.114874

关键词

Obsessive -compulsive disorder; fMRI; Cognitive reappraisal; Psychophysiological interaction analysis; Frontoparietal network; Emotion regulation

资金

  1. FLAD Science Award Mental Health 2021
  2. National funds, through the Foundation for Science and Technology [UIDB/50026/2020, UIDP/50026/2020]
  3. Norte Portugal Regional Operational Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000039]
  4. 2-CA Clinical Academic Center (Portugal)
  5. Spanish Ministry of Universities
  6. European Union NextGenerationEU [MAZ/2021/11]

向作者/读者索取更多资源

Patients with OCD show increased brain activity and altered connectivity during negative emotions, suggesting deficits in emotion regulation. They are less successful at lowering the emotional impact of negative images. Frontoparietal connectivity in OCD patients may serve as a compensatory mechanism during emotion regulation.
Patients with obsessive-compulsive disorder (OCD) present increased brain activity in orbitofrontal and limbic regions when experiencing negative emotions, which could be related to deficits in emotion regulation abilities. 30 OCD patients and 29 healthy controls (HC) performed a cognitive reappraisal functional magnetic resonance imaging (fMRI) task and completed emotion regulation and OCD symptomatology questionnaires. Besides task activation, connectivity was also compared between groups through psychophysiological interaction analysis (PPI), using regions previously reported to be hyperactive in OCD as seeds. Finally, brain-behavior correlations were performed between activation/connectivity strength in group differential regions and the questionnaires' scores, as well as the emotional ratings reported during the task. Behaviorally, patients with OCD were less successful than controls at lowering the emotional impact of negative images. At the brain level, there were no significant between-group differences in brain activation. Contrarily, PPI analyses showed that HC had increased frontoparietal connectivity when experiencing negative emotions in comparison to OCD patients, while this pattern was reversed when regulating emotions (increased connectivity in patients). Finally, frontoparietal connectivity was correlated with measures of emotion regulation success and OCD symptomatology. Our findings point towards frontoparietal altered connectivity as a potential compensatory mechanism during emotion regulation in OCD patients.

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