Evidence that the frontal pole has a significant role in the pathophysiology of schizophrenia

Different regions of the cortex have been implicated in the pathophysiology of schizophrenia. Recently published data suggested there are many more changes in gene expression in the frontal pole (Brodmann's Area (BA) 10) compared to the dorsolateral prefrontal cortex (BA 9) and the anterior cingulate cortex (BA 33) from patients with schizophrenia. These data argued that the frontal pole is significantly affected by the pathophysiology of schizophrenia. The frontal pole is a region necessary for higher cognitive functions and is highly interconnected with many other brain regions. In this review we summarise the growing body of evidence to support the hy-pothesis that a dysfunctional frontal pole, due at least in part to its widespread effects on brain function, is making an important contribution to the pathophysiology of schizophrenia. We detail the many structural, cellular and molecular abnormalities in the frontal pole from people with schizophrenia and present findings that argue the symptoms of schizophrenia are closely linked to dysfunction in this critical brain region.

Automated summary

Research suggests that the frontal pole is significantly impacted in schizophrenia, with more gene expression changes compared to other brain regions. The frontal pole is essential for higher cognitive functions and has extensive connections with various brain regions. Dysfunction in the frontal pole plays a crucial role in the pathophysiology of schizophrenia, with structural, cellular, and molecular abnormalities contributing to the symptoms of the disorder.