期刊
PROGRESS IN NEUROBIOLOGY
卷 217, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2022.102328
关键词
Astrocytes; Oxytocin; Amygdala; Hypothalamus; Neuropeptide
资金
- Universite de Strasbourg [UPR3212]
- Agence Nationale de la Recherche (ANR) Jeune Chercheuse Jeune Chercheur (JCJC) [19-CE16-0011-0]
- Graduate School of Pain EURIDOL [ANR-17-EURE-0022]
- Foundation of Prader-Willi Research post-doctoral fellowship
- Centre National de la Recherche Scientifique [UPR3212]
The neuropeptide oxytocin has been studied for its effects on physiology, neuronal circuits, and behaviors, particularly sociality. Recent studies have shown the existence and importance of astroglial oxytocin receptors in various brain regions. The role of astrocytic oxytocin receptors in neuromodulation and integrated brain functions still needs further investigation.
The neuropeptide oxytocin has been in the focus of scientists for decades due to its profound and pleiotropic effects on physiology, activity of neuronal circuits and behaviors, among which sociality. Until recently, it was believed that oxytocinergic action exclusively occurs through direct activation of neuronal oxytocin receptors. However, several studies demonstrated the existence and functional relevance of astroglial oxytocin receptors in various brain regions in the mouse and rat brain. Astrocytic signaling and activity is critical for many important physiological processes including metabolism, neurotransmitter clearance from the synaptic cleft and integrated brain functions. While it can be speculated that oxytocinergic action on astrocytes predominantly facilitates neuromodulation via the release of specific gliotransmitters, the precise role of astrocytic oxytocin receptors remains elusive. In this review, we discuss the latest studies on the interaction between the oxytocinergic system and astrocytes, including detailed information about intracellular cascades, and speculate about future research directions on astrocytic oxytocin signaling.
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