4.8 Article

A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons

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Summary: The TRPM8 mutation enhances channel activation, increases basal current amplitude and intracellular [Ca2+] in cells carrying the mutant channel, and enhances the response to menthol, suggesting gain-of-function attributes on TRPM8 contribute to trigeminal neuralgia pathogenesis in patients carrying this mutation.

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