期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2201657119
关键词
hippocampal ripples; episodic memory; contextual reinstatement; medial temporal lobe; intracranial EEG
资金
- DARPA RAM program [N66001-14-2-4032]
- NIH [R01NS106611-02]
- US Army Medical Research and Development Command Medical Technology Enterprise Consortium [MTEC-20-06-MOM-013]
Recent research shows that the frequency of hippocampal ripples increases before the free recall of recently formed memories. This effect is stronger in certain regions of the hippocampus and more prominent during the retrieval of temporally and semantically clustered memories, indicating the involvement of ripples in episodic memory reinstatement.
High-frequency oscillatory events, termed ripples, represent synchrony of neural activity in the brain. Recent evidence suggests that medial temporal lobe (MTL) ripples support memory retrieval. However, it is unclear if ripples signal the reinstatement of episodic memories. Analyzing electrophysiological MTL recordings from 245 neurosurgical participants performing episodic recall tasks, we find that the rate of hippocampal ripples rises just prior to the free recall of recently formed memories. This prerecall ripple effect (PRE) is stronger in the CA1 and CA3/dentate gyrus (CA3/DG) subfields of the hippocampus than the neighboring MTL regions entorhinal and parahippocampal cortex. PRE is also stronger prior to the retrieval of temporally and semantically clustered, as compared with unclustered, recalls, indicating the involvement of ripples in contextual reinstatement, which is a hallmark of episodic memory.
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