期刊
JOURNAL OF LUMINESCENCE
卷 175, 期 -, 页码 149-157出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jlumin.2016.02.034
关键词
Multifunctional nanoparticles; Luminescence nanothermometry; Neodymium nanoparticles; Hyperthermia; Fluorescence imaging
类别
资金
- Spanish Ministerio de Educacion y Ciencia [MAT2010-21270-C04-02]
- Brazilian Agency: FINEP (Financiadora de Estudos e Projetos) [INFRAPESQ-11, INFRAPESQ-12]
- Brazilian Agency: CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) through Grant INCT NANO (BIO)SIMES)
- Brazilian Agency: CAPES (Coordenadoria de Aperfeicoamento de Pessoal de Ensino Superior) [PVE A077/2013]
- CAPES [A077/2013]
- Post Doctoral Fellowship grant PDE/CAPES at the Universidad Autonoma de Madrid, Spain [2108-14-3]
Nd3+ ion doped LaF3 dielectric nanoparticles have recently emerged as very attractive multifunctional nanoparticles capable of simultaneous sub-tissue heating and thermal sensing. Although they have been already used for selective photothermal treatment of cancer tumors in animal models, their real application as self-monitored photothermal agents require further optimization and development. Dynamic adjustment of the therapy parameters is mandatory for non-selective damage minimization. It would require real-time (sub-second) thermal sensing with a sub-degree thermal resolution. In this work we demonstrate that meeting this challenge is, indeed, possible by performing controlled thermal treatment on as-synthesized Nd3+ doped LaF3 nanoparticles. Temperature induced lattice ordering and defect recombination have been concluded to induce, simultaneously, a line fluorescence narrowing, fluorescence brightness enhancement and a remarkable increment in thermal sensitivity. Ex-vivo experiments have demonstrated that, thanks to this multi-parameter optimization, Neodymium doped LaF3 nanoparticles are capable of real time sub-tissue thermal reading with a temperature resolution as low as 0.7 degrees C. (C) 2016 Elsevier B.V. All rights reserved.
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