Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001-2017

Vulvar cancer incidence has been rising in recent years, possibly due to increasing exposure to human papil-lomavirus (HPV). We assessed incidence rates of HPV-associated and non-HPV-associated vulvar cancers diag-nosed from 2001 to 2017 in the United States (US). Using population-based cancer registry data covering 99% of the US population, incidence rates were calculated and stratified by age, race/ethnicity, stage, geographic region, and histology. The average annual percent change in incidence per year were calculated using joinpoint regression. From 2001 to 2017, the incidence of HPV-associated vulvar cancers increased by 1.2% per year, most notably among women who were aged 50-59 years (2.6%), 60-69 years (2.4%), and >= 70 years (0.9%); of White (1.5%) and Black (1.1%) race; diagnosed at an early (1.3%) and late (1.8%) stage; and living in the Midwest (1.9%), Northeast (1.4%), and South (1.2%). Incidence increased each year for HPV-associated histologic sub-types including keratinizing (4.7%), non-keratinizing (6.0%), and basaloid (3.1%) squamous cell carcinomas (SCCs), while decreases were found in warty (2.7%) and microinvasive (5.5%) SCCs. HPV-associated vulvar cancer incidence increased overall and among women aged over 50 years while remaining stable among women younger than 50 years. The overall incidence for non-HPV-associated cancers was stable. Continued surveillance of HPV-associated cancers will allow us to monitor future trends as HPV vaccination coverage increases in the US.

Automated summary

The incidence of vulvar cancer has been rising in recent years, possibly due to increasing exposure to human papillomavirus (HPV). The highest increase in incidence rates was observed among women aged 50 and above, white and black women, and women living in the Midwest, Northeast, and South regions.