Investigation of granular dynamics in a continuous blender using the GPU-enhanced discrete element method

Continuous powder blending is an essential operation during continuous pharmaceutical manufacturing. How-ever, the complex granular dynamics in the blender is still poorly understood. This study employs a graphic processor unit (GPU) enhanced discrete element method (DEM) to analyse the granular dynamics in a continuous blender. Numerical results indicate that only a small fraction of powder distributes in the upper region of the blender, while most of that distributes in the middle and lower regions. Besides, a higher impeller speed leads to a smaller hold-up mass and a shorter mean residence time. Interestingly, the maximum number of blade passes is achieved at an intermediate impeller speed. There are two distinct regimes during continuous blending: i) a shearing regime at low impeller speeds; and ii) a dynamic regime at high impeller speeds. This study demon-strates that the GPU-enhanced DEM can be a robust tool for analysing powder flow during continuous phar-maceutical manufacturing.

Automated summary

The study uses GPU-enhanced DEM to analyze granular dynamics in a continuous blender. Results show most powder distributes in the middle and lower regions, higher impeller speed leads to smaller hold-up mass and shorter residence time, and maximum blade passes are achieved at intermediate speed.