期刊
POLYCYCLIC AROMATIC COMPOUNDS
卷 43, 期 6, 页码 5639-5734出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10406638.2022.2105911
关键词
Spiropyrazoles; synthesis; indanones; cycloaddition reactions; bioactive pyrazoles
This review collects and categorizes spiropyrazoles based on their combined rings and illustrates different synthesis methods.
Pyrazole category with all derivatives have well-known with biological and industrial applications. Pyrazole combined with other cycle (aliphatic or heterocycles) through one carbon atoms afforded spiropyrazoles. This spiropyrazoles characterized with biological importance as antitumor, analgesic, anti-inflammatory, vasodilation, aldosterone antagonistic, antimicrobial, phosphodiesterase, anabolic, androgenic, progestational, and salt-retaining activities. We interested in this review to collect and sort the spiropyrazoles according to their combined rings and illustrated the different methods of synthesis until the middle of 2021.
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